新型冠状病毒感染后富亮氨酸胶质瘤失活1蛋白抗体相关脑炎1例

A case of leucine-rich glioma-inactivated 1 antibody-associated encephalitis following coronavirus disease 2019 infection

本文报道1例70岁男性患者,新型冠状病毒感染后表现为快速进展的认知功能障碍、睡眠行为紊乱、情绪不稳定及运动障碍,曾诊断“抑郁状态、躁狂状态、痴呆原因待查”,抗抑郁药及心境稳定剂治疗无效。血清和脑脊液富亮氨酸胶质瘤失活1蛋白(leucine-rich glioma-inactivated 1,LGI1)抗体均为阳性,确诊LGl1抗体相关脑炎,经过免疫球蛋白和糖皮质激素治疗后症状明显改善。本文通过报道新型冠状病毒感染后LGI1抗体相关脑炎的临床特点,以提高临床医生对该病的认识,减少误诊误治。

This is a case report of a 70-year-old male patient with rapid progression of cognitive dysfunction,sleep behavior disturbance,emotional instability,and motor disturbance after COVID-19 infection.The patient was diagnosed with"depressive state,manic state,and dementia cause unknown",antidepressants and mood stabilizers were ineffective.Both serum and cerebrospinal fluid were positive for anti-leucine-rich glioma-inactivated protein 1(LGI1)antibodies,and"LGI1 antibody-associated encephalitis"was confirmed.All symptoms improved significantly after immunoglobulins and glucocorticoids therapy.In this case,by reviewing the clinical characteristics of LGI1 antibody-associated encephalitis after COVID-19 infection,we can improve the understanding of the disease,as well as reduce misdiagnosis and mistreatment.