畸形性骨炎:1例报告与综述

Paget's disease of bone:A case report and literature review

畸形性骨炎为骨重建异常的一种非炎症代谢性骨病,主要表现为骨痛、骨骼膨大、骨畸形和骨折。本病在国内极为罕见,其形成的主要原因尚不清楚,文献中多数认为其发生与遗传因素和环境因素相关。目前无明确诊断标准,主要依靠血碱性磷酸酶升高及特征性的影像学改变来诊断。本文报道1例畸形性骨炎的病例,结合免疫组化更加明确诊断,并通过回顾文献,着重介绍其发病机理、诊断、治疗方法,旨在为畸形性骨炎的研究与诊治提供参考。

Paget's disease of bone is a non-inflammatory metabolic bone disease characterized by abnormal bone remodeling,mainly manifested as bone pain,bone enlargement,bone deformity and fracture.This disease is extremely rare in China,and the main causes of its formation are still unclear.Most of the literatures believe that its occurrence is related to genetic factors and environmental factors.At pres⁃ent,there are no clear diagnostic criteria,which mainly rely on elevated blood alkaline phosphatase and characteristic imaging changes.In this paper,a case of Paget's disease of bone was reported,who was definitively diagnosed by combining with immunohistochemistry.By re⁃viewing the literature,the pathogenesis,diagnosis and treatment of the malformed osteitis were mainly introduced in order to provide refer⁃ence for the research,diagnosis and treatment of Paget's disease of bone.