摘要
目的探讨四肢创伤性软组织缺损(STI)患者游离皮瓣移植(FFT)修复失败的危险因素,并构建预测模型。方法选取2017年1月至2023年6月期间行FFT的575例四肢创伤性STI患者为研究对象,7︰3随机分为建模组(n=403)和验证组(n=172)。多因素Logistic回归分析确定四肢创伤性STI患者FFT修复失败的危险因素。利用R3.6.3软件中rms程序包构建预测四肢创伤性STI患者FFT修复失败的列线图模型,并采用受试者工作特征(ROC)曲线和霍斯默-莱梅肖(H-L)拟合度曲线,对列线图模型预测区分度和一致性进行评估。结果多因素Logistic回归分析显示,受伤至手术时间≥6 h(OR=2.179)、吻合血管选择不合理(OR=6.770)、并发感染(OR=4.980)、术中止血不彻底(OR=3.054)、术后固定不牢固(OR=2.132)等,均为四肢创伤性STI患者FFT修复失败的独立危险因素(P<0.05);建模组H-L检验χ^(2)=11.889、P=0.546,ROC曲线下面积为0.809(95%CI:0.748~0.869);验证组H-L检验χ^(2)=6.990、P=0.322,ROC曲线下面积为0.827(95%CI:0.722~0.932)。结论基于受伤至手术时间、吻合血管选择、并发感染、术中止血不彻底、术后固定不牢固等5个危险因素构建的预测四肢创伤性STI患者FFT修复失败的列线图模型具有较好的区分度和一致性。
Objective To explore the risk factors for failure of free flap transplantation(FFT)in patients with traumatic soft tissue injury(STI)of limbs,and to construct a predictive model.Methods A total of 575 patients with traumatic STI in the limbs who underwent FFT from January 2017 to June 2023 were regarded as the study subjects.The patients were randomly separated into a modeling group(n=403)and a validation group(n=172)at 7:3.Multivariate Logistic regression analysis was applied to determine the risk factors for FFT repair failure in patients with traumatic STI of the limbs.The RMS program package in R3.6.3 software was applied to construct a column graph model for predicting the failure of FFT repair in patients with traumatic STI of limbs,receiver operating characteristic(ROC)curve and the Hosmer-Lemeshow(H-L)fit curve were applied to evaluate the discrimination and consistency of the column plot model prediction.Results The results of multivariate Logistic regression analysis showed that the time from injury to surgery≥6 hours(OR=2.179),unreasonable selection of anastomosis vessels(OR=6.770),concurrent infection(OR=4.980),incomplete intraoperative hemostasis(OR=3.054),and unstable postoperative fixation(OR=2.132)were all independent risk factors for FFT repair failure in patients with traumatic STI of limbs(P<0.05).The H-L test of the modeling group showedχ^(2)=11.889,P=0.546,and the area under the ROC curve was 0.809(95%CI:0.748-0.869);The H-L test of the validation group showedχ^(2)=6.990,P=0.322,and the area under the ROC curve was 0.827(95%CI:0.722-0.932).Conclusion Based on five risk factors:Time from injury to surgery,selection of anastomotic vessels,concurrent infection,incomplete intraoperative hemostasis,and unstable postoperative fixation,the column chart model for predicting the failure of FFT repair in patients with traumatic STI of limbs has good discrimination and consistency.
作者
宋春林
罗成军
朱雨
SONG Chunlin;LUO Chengjun;ZHU Yu(Leshan City People's Hospital,Leshan 614000,China)
出处
《组织工程与重建外科》
CAS
2024年第3期305-311,共7页
Journal of Tissue Engineering and Reconstructive Surgery
关键词
四肢创伤性软组织缺损
游离皮瓣移植
危险因素
预测模型
Traumatic soft tissue injury of limbs
Free flap transplantation
Risk factors
Prediction model