血液灌流治疗重度有机磷中毒的效果研究

Study on the effect of hemoperfusion in the treatment of severe organophosphate poisoning

目的分析血液灌流在重度有机磷中毒治疗中的应用效果,为制订临床治疗方案提供参考。方法选取2021年3月—2022年10月高唐县人民医院收治的重度有机磷中毒患者82例,随机分为对照组和观察组各41例。对照组实施常规内科治疗,观察组实施血液灌流治疗。比较两组临床指标、并发症发生率及临床检验指标。结果观察组意识恢复时间、机械通气时间、胆碱酯酶恢复时间、住院时间均短于对照组,差异均有统计学意义(P<0.05)。观察组并发症发生率为12.20%,低于对照组的31.71%,差异有统计学意义(χ^(2)=4.556,P<0.05)。治疗后,观察组超敏C反应蛋白(hsCRP)、血清胆碱酯酶(CHE)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)水平均优于对照组,差异均有统计学意义(P<0.05)。结论血液灌流有助于降低重度有机磷中毒患者并发症发生率,缩短治疗时间,改善患者临床预后,值得临床推广应用。

Objective To analyze the application effect of hemoperfusion in the treatment of severe organophosphate poisoning,and to provide reference for formulating clinical treatment plans.Methods A total of 82 patients with severe organophosphorus poisoning admitted to Gaotang County People's Hospital from March 2021 to October 2022 were selected and randomly divided into control group and observation group,with 41 cases in each group.The control group received routine internal medicine treatment,while the observation group received hemoperfusion treatment.The clinical indicators,incidence of complicatons and clinical test indicators of two groups were compared.Results The consciousness recovery time,mechanical ventilation time,cholinesterase recovery time and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The incidence of complications in the observation group was 12.20%,which was lower than 31.71%in the control group,and the difference was statistically significant(χ^(2)=4.556,P<0.05).After treatment,the levels of high-sensitivity C-reactive protein(hs-CRP),serum cholinesterase(CHE),lactate dehydrogenase(LDH)and creatine kinase isoenzyme(CK-MB)in the observation group were better than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Hemoperfusion could help reduce the incidence of complications in patients with severe organophosphate poisoning,shorten treatment time and improve clinical prognosis,which was worthy of clinical promotion and application.