HIV蛋白在HIV感染者肿瘤发生机制中的作用及研究进展

The role and research progress of HIV-encoded proteins in tumorigenesis among HIV-infected individuals

HIV基因编码的基质蛋白p17、糖蛋白gp120、反转录酶、Tat蛋白和Nef蛋白等广泛参与了肿瘤细胞的增殖与侵袭,且与肿瘤微环境的形成密切相关。近年来,有关HIV基因编码蛋白对HIV感染者肿瘤发生、发展进程以及调控机制有较多进展。本文就HIV基因编码蛋白对HIV相关肿瘤的调控机制进行综述。

HIV-encoded proteins, including the matrix protein p17, glycoprotein gp120, reverse transcriptase, Tat, and Nef, play extensive roles in the proliferation and metastasis of tumor cells and are closely associated with the formation of the tumor microenvironment. In recent years, there has been significant progress in understanding how HIV-encoded proteins influence tumor initiation, progression, and the underlying regulatory mechanisms in individuals infected with HIV. This article provides a comprehensive review of the regulatory mechanisms exerted by HIV-encoded proteins on HIVassociated tumors.