腺泡细胞死亡模式在急性胰腺炎中的研究进展

Research progress in acinar cell death model in acute pancreatitis

急性胰腺炎(AP)是一种累及胰腺局部和全身的炎性疾病,通常呈自限性,但仍有20%的患者易发展为重症急性胰腺炎(SAP),从而导致全身炎症反应综合征和累及肺、肾、肝和心脏等多器官功能障碍和衰竭.SAP患者易出现糖尿病、胰腺外分泌功能障碍、慢性胰腺炎等远期并发症,严重影响生活质量.胰腺腺泡细胞损伤与死亡是AP早期发生的主要病理生理特点,目前研究表明不同细胞死亡模式在AP的发生发展中发挥重要作用,本文就此展开综述,为AP的发病机制和治疗提供新的认识和调控靶点.

Acute pancreatitis(AP)is a disease of inflammation that accumulates locally and throughout the pancreas and is usually self-limiting,but still predisposes 20%of patients to develop severe acute pancreatitis(SAP),which results in systemic inflammatory response syndrome and cumulative multi-organ dysfunction and failure of the lungs,kidneys,liver,and heart.SAP patients are prone to diabetes,pancreatic exocrine dysfunction,chronic pancreatitis and other long-term complications,which seriously affect the quality of life.Pancreatic acinal cell injury and death are the main pathophysiological features of the early development of AP.Current studies have shown that different cell death modes play an important role in the occurrence and development of AP.This review provides new understanding and regulatory targets for the pathogenesis and treatment of AP.