吸入用布地奈德混悬液与盐酸左沙丁胺醇雾化吸入溶液药物治疗急性加重期COPD的效果

Effect of Choosing Budesonide Suspension and Levofloxacin Hydrochloride Nebulized Inhalation Solution for Acute Aggravated Chronic Obstructive Pulmonary Disease Patients

目的观察急性加重期慢性阻塞性肺疾病(COPD)患者选择雾化吸入布地奈德与盐酸左沙丁胺醇治疗的价值。方法回顾性选取2022年2月至2023年2月漳浦县医院急性加重期COPD患者98例,依据用药方法的不同分为两组,各49例。联合用药组接受盐酸左沙丁胺醇雾化吸入溶液与吸入用布地奈德混悬液药物治疗,单独用药组接受单独吸入用布地奈德混悬液药物治疗,对两组血气分析与肺功能监测结果、凝血指标、临床疗效、症状控制与缓解时间、住院时间进行统计分析。结果联合用药组患者的氧分压(PaO_(2))、pH值、最大呼气流量(PEF)、第1秒用力呼气容积(FEV_(1))、用力呼气量(FVC)、FEV_(1)/FVC、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均高于单独用药组(P<0.05),动脉血二氧化碳分压(PaCO_(2))低于单独用药组(P<0.05),总有效率高于单独用药组(P<0.05),急性发作控制时间与喘息、哮鸣音、咳嗽缓解时间及住院时间均短于单独用药组(P<0.05)。结论急性加重期COPD患者选择雾化吸入布地奈德与盐酸左沙丁胺醇的价值较高,更能对患者的血气分析与肺功能、凝血功能进行改善,临床疗效更为显著,且更能将患者的症状控制与缓解时间、住院时间缩短。

Objective To observe the value of nebulized inhalation of budesonide+levsalbutamol hydrochloride in acute exacerbation of chronic obstructive pulmonary disease patients.Methods A retrospective selection was conducted on 98 acute exacerbation of chronic obstructive pulmonary disease(COPD)patients in Zhangpu County Hospital from February 2022 to February 2023.According to medication methods,they were divided into two groups,with 49 patients in each group.The combination therapy group received nebulized inhalation solution of levofloxacin hydrochloride and treatment with budesonide suspension for inhalation,while the monotherapy group received treatment with budesonide suspension for inhalation alone.Perform statistical analysis on the results of blood gas analysis and lung function monitoring,coagulation indicators,clinical efficacy,symptom control and relief time,and length of hospital stay for two groups.Results The partial pressure of oxygen(PaO_(2)),pH value,maximum expiratory flow(PEF),forced expiratory volume(FEV_(1)),forced expiratory volume(FVC),FEV_(1)/FVC,prothrombin time(PT)and activated partial thromboplastin time(APTT)in combined therapy group were higher than those monotherapy group(P<0.05).The partial pressure of arterial blood carbon dioxide(PaCO_(2))in combined therapy group was lower than that in the monotherapy group(P<0.05),the total effective rate was higher than that in the monotherapy group(P<0.05),and the duration of acute attack control,wheezing,wheezing,cough relief and hospital stay were shorter than that in the monotherapy group(P<0.05).Conclusions The value of nebulized inhalation of budesonide+levsalbutamol hydrochloride is higher in acute exacerbation of chronic obstructive pulmonary disease patients.It can better improve the blood gas analysis,lung function,and coagulation function of patients,resulting in more significant clinical efficacy.It can also better control and alleviate symptoms,shorten hospital stay,and shorten hospital stay.