血清炎性因子与宫颈癌根治术治疗预后的相关性研究

A Study on the Correlation Between Serum Inflammatory Factors and the Prognosis of Radical Cervical Cancer Treatment

目的探讨血清炎性因子白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)及γ干扰素(INF-γ)与宫颈癌手术患者预后相关性,为临床预后评估提供依据。方法回顾性研究2021年2月至2022年2月在接受根治术的120例宫颈癌患者的临床资料,均在术前接受血清炎性因子(IL-6、TNF-α及INF-γ)检测,随访掌握患者的预后,对比分析不同预后患者临床病理特征、血清炎性指标水平差异,并进行多因素回归分析影响预后的风险因素。结果本组患者随访平均(14.52±2.30)个月,预后良好84例、预后不良36例;通过分析,两组肿瘤分期、分化程度及血清IL-6、TNF-α、INF-γ差异存在统计学意义(P<0.05),年龄、肿瘤直径、病理分型、淋巴结转移无明显差异(P>0.05)。Logistic回归分析结果表明,分化程度、血清IL-6、TNF-α、INF-γ是影响宫颈癌预后独立风险因素(P<0.05)。结论术前血清炎性因子水平会影响宫颈癌根治术预后,可作为临床诊治及预后评估的重要生物学标志物。

Objective To investigate the serum inflammatory factor interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and Interferon-γ(INF-γ)is correlated with the prognosis of patients undergoing cervical cancer surgery,which provides a basis for clinical prognosis evaluation.Methods A retrospective study was conducted on the clinical data of 120 patients with cervical cancer who underwent radical surgery from February 2021 to February 2022.Serum inflammatory factors(IL-6,TNF-αand INF-γ)were detected before surgery,the prognosis of patients was followed up,and the clinicopathological features and serum inflammatory indicators of patients with different prognosis were compared and analyzed.Parallel multifactor regression analysis was performed to determine the influence of risk factors on prognosis.Results The patients were followed up for an average of(14.52±2.30)months,with good prognosis in 84 cases and poor prognosis in 36 cases.By analysis,there were significant differences in tumor stage,differentiation degree,serum IL-6,TNF-αand INF-γbetween the two groups(P<0.05),but no significant differences in age,tumor diameter,pathological type and lymph node metastasis between the two groups(P>0.05).Logistic regression analysis showed that differentiation degree,serum IL-6,TNF-αand INF-γwere independent risk factors for the prognosis of cervical cancer(P<0.05).Conclusions Preoperative serum inflammatory factor level can affect the prognosis of cervical cancer after radical resection,and can be used as an important biomarker for clinical diagnosis,treatment and prognosis evaluation.