重金属与α-突触核蛋白相互作用在帕金森病中的研究进展

Research progress of the interaction between heavy metals andɑ-synuclein in Parkinson′s disease

帕金森病是一种神经退行性病变,其病理标志物ɑ-突触核蛋白(ɑ-syn)的水平异常往往伴有重金属稳态失衡,但目前其具体机制尚不明确,相关研究较少。本综述主要探讨在帕金森病的发生及发展过程中,4种重金属(铁、铜、锌和锰)与病理性ɑ-syn异常表达、聚集和降解之间的相互作用机制,同时阐述并展望了针对帕金森病患者重金属失衡的潜在治疗方向。

Parkinson′s disease(PD)is a neurodegenerative disorder,and the abnormal levels of its pathological markerɑ-synuclein(ɑ-syn)are often accompanied by imbalanced heavy metal homeostasis.However,the underlying mechanisms remain unclear,with limited research.This review explores the interactions between iron,copper,zinc,and manganese with pathologicalɑ-syn′s abnormal expression,aggregation,and degradation in development and progression of PD.It also discusses potential therapeutic directions for addressing heavy metal imbalances in PD patients.