甲苯磺酸多纳非尼片致多形红斑型药疹1例分析

One case of erythema multiforme drug eruption caused by donafenib tosilate tablets

目的探讨甲苯磺酸多纳非尼片(简称“多纳非尼”)罕见全身皮肤不良反应临床特征及发生机制。方法对1例胆囊恶性肿瘤患者应用多纳非尼致罕见皮肤毒性病例分析,结合相关文献,分析临床表现及发生机制。结果患者主要表现为全身散在非典型靶形红斑、瘙痒、发热,与多形红斑型药疹的临床表现相似,予停用多纳非尼,使用激素、人免疫球蛋白、抗组胺治疗后症状明显缓解。结论多纳非尼致多形红斑型药疹罕见且严重,应引起重视,目前国内外尚未有相关报道,多纳非尼为索拉非尼衍生物,考虑其发生机制与其相似。

Objective To explore the clinical characteristics and mechanism of rare systemic skin adverse reactions caused by donafenib tosilate tablets(donafenib).Methods Rare skin toxicity caused by donafenib in a patient with gallbladder malignant tumor was analyzed while the manifestations and pathogenesis were summarized based on literature review.Results The clinical manifestations of this patient including atypical target erythema,pruritus and fever were similar to those of erythema multiforme drug eruption.After discontinuation of donafenib and treatment with hormone,human immunoglobulin and antihistamine drugs,the symptoms were significantly relieved.Conclusion Erythema multiforme drug eruption induced by donafenib is rare but severe,which deserves more attention.There have been no related reports at home and abroad.Donafenib is a derivative of sorafenib so that the pathogenesis is similar.