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维生素C辅助阿奇霉素序贯疗法治疗肺炎支原体肺炎儿童的疗效

Efficacy of vitamin C assisted azithromycin sequential therapy in children with Mycoplasma pneumoniae pneumonia
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摘要 目的探究维生素C辅助阿奇霉素序贯疗法治疗肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)儿童的临床疗效,分析对血清免疫球蛋白和CD4^(+)/CD8^(+)值的影响。方法选取收治的MPP患儿120例为研究对象,随机分为观察组和对照组,各60例。对照组接受阿奇霉素序贯疗法,观察组在对照组治疗的基础上联合维生素C辅助治疗。比较2组的临床疗效,治疗前后的肺功能[第1秒用力呼气容积(forced expiratory volume forced in one second,FEV1)、用力肺活量(forced vital capacity,FVC)、最高呼气峰流速(peak expiratory flow,PEF)]、血清免疫球蛋白[免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白M(immunoglobulin M,IgM)]以及淋巴细胞亚群[CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)]水平变化。结果观察组的治疗总有效率(91.67%)高于对照组(78.33%),P<0.05。观察组的FEV1、FVC和PEF水平高于对照组,血清IgA、IgG和IgM水平高于对照组,CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)高于对照组(P<0.05)。结论维生素C辅助阿奇霉素序贯疗法治疗MPP患儿可提高临床疗效,显著改善患儿的肺功能和免疫功能,具有良好的临床应用价值。 Objective To investigate the clinical effect of vitamin C assisted azithromycin sequential therapy in the treatment of children with Mycoplasma pneumoniae pneumonia(MPP),and to analyze the influence on serum immunoglobulins and CD4^(+)/CD8^(+)ratio.Methods A total of 120 children with MPP were randomly divided into observation group and control group,with 60 cases in each.The control group received azithromycin sequential therapy,while the observation group received vitamin C assisted azithromycin sequential therapy.The clinical effect and changes in pulmonary function[forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and peak expiratory flow(PEF)],serum immunoglobulins[immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)]and lymphocyte subsets(CD3^(+),CD4^(+)and CD4^(+)/CD8^(+))before and after treatment were compared between the groups.Results The total treatment response rate in the observation group(91.67%)was higher than that in the control group(78.33%),P<0.05.After treatment,the FEV1,FVC,PEF,serum IgA,IgG and IgM levels,and the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05).Conclusion Vitamin C assisted azithromycin sequential therapy can improve the clinical effect of treatment and significantly improve the pulmonary function and immune function in children with MPP.
作者 郑武田 方辉 魏守缙 刘梦莹 黄婷婷 ZHENG Wutian;FANG Hui;WEI Shoujin;LIU Mengying;HUANG Tingting(Department of Pediatrics,District of Heping Road,the Second People’s Hospital of Hefei,Hefei 230011,China)
出处 《西北药学杂志》 CAS 2024年第4期126-129,共4页 Northwest Pharmaceutical Journal
基金 安徽省医药卫生科技计划项目(编号:C2020zyrc159)。
关键词 维生素C 阿奇霉素序贯疗法 肺炎支原体 肺炎 免疫球蛋白 T淋巴细胞亚群 vitamin C azithromycin sequential therapy Mycoplasma pneumoniae pneumonia immunoglobulin T lymphocyte subset
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