基于数据挖掘含黄芩治疗肿瘤相关抑郁方用药规律研究

Research on the medication rule of prescription containing Scutellariae Radix in the treatment of tumor-related depression based on data mining

目的基于数据挖掘探讨含黄芩治疗肿瘤相关抑郁方剂用药规律及配伍方法。方法在中国知网、万方数据知识服务平台和维普数据库检索建库至2022年12月临床治疗肿瘤相关抑郁的文献,建立处方数据库。运用频数分析、关联分析、复杂网络分析含黄芩治疗肿瘤相关抑郁方剂的用药规律。结果共筛选出处方45首,包含中药86味,高频中药(柴胡、半夏、人参、龙骨、牡蛎、茯苓、郁金、合欢皮、丹参、石菖蒲、远志、酸枣仁、大黄)13味。配伍规律方面,以配伍理气药为主,安神、补益、化痰、清热为辅。主治病证的病位在肝,邪实为主,热证居多,肝郁化火型是最常见的证型。涉及症状31个,其中高频症状(抑郁、食欲不振、胁肋胀痛、心情低落、口苦、咽干、烦躁、胸闷、失眠多梦、情绪不宁、疲乏、大便秘结、心烦、易怒、脘痞腹胀)15个。关联规则显示与黄芩配伍的常用药对有柴胡→半夏、柴胡→人参、牡蛎→龙骨、柴胡→龙骨、柴胡→牡蛎,复杂网络分析显示常用药物组合以柴胡加龙骨牡蛎汤类为主,可能是治疗肿瘤相关抑郁的核心组方。结论含黄芩治疗肿瘤相关抑郁方以配伍理气药为主,安神、补益、化痰、清热为辅,有效改善抑郁、食欲不振、胁肋胀痛、心情低落等症状,为临床治疗肿瘤相关抑郁提供新思路。

Objective To investigate the medication rule and compatibility method of prescription containing Scutellariae Radix in the treatment of tumor-related depression based on data mining.Methods The literatures on clinical treatment of tumor-related depression were searched in CNKI,Wanfang Data and VIP databases,with the retrieval time duration from the database establishment to December 2022,and the prescription database was established.Frequency analysis,correlation analysis and complex network analysis were used to analyze the medication rule of prescription containing Scutellariae Radix in the treatment of tumor-related depression.Results A total of 45 prescriptions were screened out,including 86 Chinese materia medica and 13 highfrequency Chinese materia medica(Radix Bupleuri,Pinellia Ternata,Ginseng,Dragons Bone,Oyster Shell,Poria Cocos,Radix Curcumae,Silktree Albizia Bark,Danshen Root,Acorus Tatarinowii,Yuanzhi,Spine Date Seed and Chinese Rhubarb).In the aspect of compatibility rule,the compatibility of qi-regulating drugs was the main focus,supplemented by tranquilizing,tonifying,resolving phlegm and clearing heat.The main treatment syndrome was located in the liver,with pathogenic excess as the main factor,and heat syndrome as the majority,and the commonest syndrome type was liver depression and heat transformation.There were 31 symptoms involved,including 15 high-frequency symptoms(depression,loss of appetite,hypochondriac pain,depressed mood,bitter mouth,dry throat,irritability,chest tightness,insomnia and dreaminess,restless mood,fatigue,constipation,upset,irritability,and epigastric distension).Association rules showed that the commonly used drug compatible with Scutellariae Radix were Radix Bupleuri→Pinellia Ternata,Radix Bupleuri→Ginseng,Oyster Shell→Dragons Bone,Radix Bupleuri→Dragons Bone and Radix Bupleuri→Oyster Shell.Complex network analysis showed that the commonly used drug combinations were mainly Chinese thorowax root combined with Os Draconis and oyster shell decoction,which might be the core prescription in the treatment of tumor-related depression.Conclusion The prescription containing Scutellariae Radix in the treatment of tumor-related depression is mainly based on compatibility of qi-regulating drugs,supplemented by tranquilizing,tonifying,resolving phlegm and clearing heat,which can effectively alleviate symptoms such as depression,loss of appetite,hypochondriac pain and depression,and provide a new idea for clinical treatment of tumor-related depression.