趋化因子CCL193′UTR rs2227302单核苷酸多态性与急性心肌梗死发生相关性

Association between chemokine CCL193′UTR rs2227302 single nucleotide polymorphism and occurrence of acute myocardial infarction

目的分析趋化因子CCL193′UTR rs2227302单核苷酸多态性与急性心肌梗死发生的相关性。方法将北部战区总医院自2009年3月至2011年9月收治的135例急性心肌梗死患者纳入梗死组;另将同期经冠状动脉造影检测显示阴性的113例对照者纳入正常组。比较两组研究对象的一般临床资料、基因型分布频率及CCL19表达水平,并采用Logistic回归分析急性心肌梗死发生的危险因素。结果梗死组男性、合并高血压、吸烟比例,以及体质量指数、总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平均高于正常组,差异有统计学意义(P<0.05)。正常组和梗死组C和T等位基因分布频率比较,差异均有统计学意义(P<0.05)。CCL193′UTR rs2227302位点的T等位基因为急性心肌梗死发生的独立危险因素(P<0.05)。梗死组CCL19表达水平高于正常组,差异有统计学意义(P<0.05)。在正常组和梗死组中,携带TT+CT型基因者的CCL19表达水平均高于携带CC+CT型基因者,差异有统计学意义(P<0.05)。结论急性心肌梗死患者血浆中CCL19表达水平升高,CCL193′UTR rs2227302单核苷酸多态位点T等位基因可能是急性心肌梗死发生的危险因素。

Objective To analyze the association between chemokine CCL193′UTR rs2227302 single nucleotide polymorphism and the occurrence of acute myocardial infarction.Methods A total of 135 patients with acute myocardial infarction admitted from March 2009 to September 2011 in the General Hospital of Northern Theater Command were included in the infarction group.In addition,113 controls with negative coronary angiography were included in the normal group.The general clinical data,genotype distribution frequency and CCL19 expression level of the two groups were compared,and the risk factors of acute myocardial infarction were analyzed by Logistic regression.Results The proportion of men,hypertension,smoking and body mass index,total cholesterol,triglyceride,low density lipoprotein cholesterol in infarction group were higher than those in normal group,with statistical significance(P<0.05).There were significant differences in the distribution frequency of C and T alleles between normal group and infarction group(P<0.05).The T allele of CCL193′UTR rs2227302 was an independent risk factor for acute myocardial infarction(P<0.05).The expression level of CCL19 in infarction group was higher than that in normal group,and the difference was statistically significant(P<0.05).In both normal group and infarction group,the expression level of CCL19 in TT+CT genotype carriers was higher than that in CC+CT genotype carriers,and the difference was statistically significant(P<0.05).Conclusion The expression level of CCL19 in plasma is increased in patients with acute myocardial infarction,and the T allele of CCL193′UTR rs2227302 single nucleotide polymorphic site may be a risk factor for acute myocardial infarction.