铁死亡在阿尔茨海默病中的作用

The Role of Ferroptosis in Alzheimer's Disease

铁死亡是一种新发现的细胞程序性死亡方式,主要由细胞内铁依赖性脂质过氧化物积累引起,在形态学、生物化学和遗传学上不同于以往报道的细胞凋亡、坏死和自噬。阿尔茨海默病(AD)是最常见的神经退行性疾病,其病理特征包括神经纤维缠结、老年斑及铁的异常沉积等,提示铁死亡可能参与其发病的进展。探讨铁死亡的发生机制及其在AD中的作用,以期为铁死亡在神经退行性疾病中的研究提供参考。

Ferroptosis is a newly discovered mode of programmed cell death,mainly caused by the accumulation of iron dependent lipid peroxides in the cell,which is different from apoptosis,necrosis and autophagy in morphology,biochemistry and genetics.Alzheimer's disease(AD)is the most common neurodegenerative disease,and its pathological features include neurofibrillary tangles,age spots and abnormal iron deposition,suggesting that ferroptosis may be involved in the progression of its pathogenesis.Exploring the mechanism of ferroptosis and its role in AD,in order to provide reference for the study of ferroptosis in neurodegenerative diseases.