2型糖尿病患者中血清C肽与糖化血红蛋白联合检测的诊断价值

Diagnostic Value of Serum C-peptide Combined with Glycated Hemoglobin A1c in Patients with Type 2 Diabetes Mellitus

目的综合分析2型糖尿病患者中血清C肽与糖化血红蛋白(Glycated Hemoglobin A1c,HbA1c)联合检验的诊断价值。方法选取泉州市中医院于2022年4月-2023年4月收治的80例疑似2型糖尿病患者为研究对象,以口服糖耐试验结果为金标准,分析血清C肽与HbA1c单一检测、联合检测的阳性检出结果、诊断效能(准确度、灵敏度、特异度)。结果口服糖耐量试验检出阳性69例,阴性11例;血清C肽单一检出真阳性54例,真阴性4例;HbA1c单一检出真阳性57例,真阴性6例;血清C肽与HbA1c联合检出真阳性66例,真阴性9例。血清C肽与HbA1c联合检测的准确度、灵敏度分别为93.75%、95.65%,均高于单一检测,差异有统计学意义(P均<0.05)。联合检测的特异度为81.82%,高于单一检测,但差异无统计学意义(P>0.05)。结论血清C肽与HbA1c是2型糖尿病临床诊断中价值较高的评估指标,其联合检测可以客观地评价患者的血糖水平,有助于对糖尿病的早期筛查、诊断,从而为后续治疗提供依据。

Objective To comprehensively analyze the diagnostic value of serum C-peptide combined with glycated hemoglobin A1c(HbA1c)in patients with type 2 diabetes mellitus.Methods Eighty patients with suspected type 2 diabetes mellitus admitted to Quanzhou Hospital of Traditional Chinese Medicine from April 2022 to April 2023 were selected as the research objects,and the results of oral glucose tolerance test were used as the gold standard.The positive detection results and diagnostic efficiency(accuracy,sensitivity and specificity)of single and combined detection of serum C-peptide and HbA1c were analyzed.Results The oral glucose tolerance test detected 69 positive cases and 11 negative cases.Serum C-peptide was detected in 54 true positive cases and 4 true negative cases.HbA1c was detected in 57 true positive cases and 6 true negative cases.Serum C-peptide combined with HbA1c was found to be true positive in 66 cases and true negative in 9 cases.The accuracy and sensitivity of the combined detection of serum C-peptide and HbA1c were 93.75%and 95.65%,respectively,which were higher than that of single detection,and the differences were statistically significant(both P<0.05).The specificity of combined detection was 81.82%,which was higher than that of single detection,but the difference was not statistically significant(P>0.05).Conclusion Serum C-peptide and HbA1c are very valuable evaluation indicators for the clinical diagnosis of type 2 diabetes mellitus,and their combined detection can objectively evaluate the blood glucose level of patients,contribute to the early screening and diagnosis of diabetes,and provide a basis for follow-up treatment.