格列美脲联合沙格列汀对2型糖尿病合并肥胖患者血糖水平、体重指数与胰岛素抵抗的影响研究

Effects of Glimepiride Combined with Shagliptin On Blood Glucose Level,Body Mass Index And Insulin Resistance in Obese Patients with Type 2 Diabetes Mellitus

目的探讨格列美脲联合沙格列汀对2型糖尿病合并肥胖患者血糖水平、体重指数与胰岛素抵抗的影响。方法选取2021年1月-2022年11月于东营市东营区中心医院接受治疗的136例2型糖尿病伴肥胖患者为研究对象,随机数表法分为对照组和观察组,每组68例。对照组接受格列美脲治疗,观察组接受格列美脲联合沙格列汀治疗。比较两组血糖水平、体重指数、血脂水平、胰岛功能。结果治疗后,两组各项血糖指标水平均有显著下降,且观察组下降更为明显,差异有统计学意义(P均<0.05)。两组体重指数和各项血脂水平均有所降低,且观察组下降幅度更为显著,差异有统计学意义(P均<0.05)。两组空腹胰岛素水平和胰岛素抵抗指数水平均降低,而胰岛β细胞功能指数水平提高,观察组各项指标改善情况优于对照组,差异有统计学意义(P均<0.05)。结论格列美脲联合沙格列汀对2型糖尿病合并肥胖患者临床效果满意,强调了药物治疗与生活方式干预相结合的重要性。

Objective To investigate the effects of glimepiride combined with saxagliptin on blood glucose levels,body mass index and insulin resistance in patients with type 2 diabetes mellitus combined with obesity.Methods A to-tal of 136 patients with type 2 diabetes mellitus and obesity who received treatment in Dongying Central Hospital from January 2021 to November 2022 were selected as the study objects and divided into control group and observation group by random number table method,with 68 cases in each group.The control group was treated with glimepiride and the observation group was treated with glimepiride combined with saxagliptin.Blood glucose level,body mass in-dex,blood lipid level,islet function were compared between the two groups.Results After treatment,the levels of vari-ous blood glucose indexes in both groups were significantly decreased,and the decrease was more obvious in the ob-servation group,the differences were statistically significant(all P<0.05).Body mass index and various lipid levels in both groups were decreased,and the decrease in the observation group was more significant,the differences were sta-tistically significant(all P<0.05).Fasting insulin level and insulin resistance index were decreased in both groups,while isletβcell function index was increased,the improvement of various indexes in observation group was better than that in control group,the differences were statistically significant(all P<0.05).Conclusion Glimepiride com-bined with saxagliptin has a satisfactory clinical effect on patients with type 2 diabetes mellitus combined with obe-sity,emphasizing the importance of combining pharmacological treatment with lifestyle intervention.