小柴胡汤在2型糖尿病治疗中的应用价值分析

Application Value of Xiaochaihu Decoction in the Treatment of Type 2 Diabetes Mellitus

目的研讨小柴胡汤在2型糖尿病(Type 2 Diabetes Mellitus,T2DM)治疗中的应用价值。方法选取2021年5月-2023年8月安溪县中医院收治的80例T2DM患者为研究对象,将其按照随机数表法分为两组。对照组(40例)予以常规基础治疗,观察组(40例)基于对照组治疗条件予以小柴胡汤辅治,对比两组不同治疗阶段的血糖指标、中医证候积分及用药安全性。结果治疗后,观察组糖化血红蛋白、空腹血糖及餐后2 h血糖水平低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组3项中医证候(口渴多饮、消谷善饥及口干舌燥)积分较对照组更低,差异有统计学意义(P均<0.05)。两组不良反应发生率比较(10.00%vs 5.00%),差异无统计学意义(χ^(2)=0.180,P=0.671)。结论小柴胡汤能够辅助降低T2DM患者的血糖水平,降低患者的中医证候,并保障用药安全性。

Objective To study the application value of Xiaochaihu decoction in the treatment of type 2 diabetes melli-tus(T2DM).Methods A total of eighty T2DM patients admitted to Anxi County Hospital of Traditional Chinese Medi-cine from May 2021 to August 2023 were selected as the study objects and divided into two groups according to ran-dom number table method.The control group(40 cases)was given routine basic treatment,and the observation group(40 cases)was given Xiaochaihu decoction based on the treatment conditions of the control group to adjuvant treapy.Blood glucose index,TCM syndrome score and drug safety were compared between the two groups at different treat-ment stages.Results After treatment,the levels of glycated hemoglobin A1c,fasting blood glucose and 2-hour post-prandial plasma glucose in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the scores of three traditional Chinese medicine syndroms(exces-sive thirst,excessive hunger and dry mouth)in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of ad-verse reactions between the two groups(10.00%vs 5.00%)(χ^(2)=0.180,P=0.671).Conclusion Xiaochaihu decoction can help reduce the blood glucose level of T2DM patients,improve the TCM syndromes of patients,and ensure the safety of medication.