酮症酸中毒为首发症状的小儿糖尿病临床治疗效果研究

Clinical Treatment Effect of Pediatric Diabetes with Ketoacidosis as the First Symptom

目的探讨首发症状为酮症酸中毒的小儿糖尿病进行胰岛素静脉滴注的临床疗效。方法选取2019年1月-2024年1月龙岩人民医院收治的首发症状为酮症酸中毒的80例患儿为研究对象,根据随机排列表法分为常规组(n=40,诺和灵R+诺和灵N)和研究组(n=40,诺和灵R+地特胰岛素)。比较两组患儿治疗效果、血糖(空腹血糖、餐后2 h血糖)水平和并发症发生情况。结果研究组住院时间、尿酮体消除时间和血pH值恢复时间均显著低于常规组,差异有统计学意义(P均<0.05)。治疗后,两组患儿空腹血糖、餐后2 h血糖水平均较治疗前降低,且研究组低于常规组,差异有统计学意义(P均<0.05)。研究组并发症总发生率(2.50%)低于常规组(20.00%),差异有统计学意义(χ^(2)=4.507,P<0.05)。结论对首发症状为酮症酸中毒的小儿糖尿病患儿应用诺和灵R联合地特胰岛素治疗,其临床治疗效果较好,并能降低患儿血糖水平和并发症发生率。

Objective To investigate the clinical effect of intravenous insulin infusion in children with diabetes melli-tus whose first symptom was ketoacidosis.Methods A total of eighty children with the first symptom of ketoacidosis admitted to Longyan People's Hospital from January 2019 to January 2024 were selected as the study objects,and they were divided into the conventional group(n=40,Novalurin R+Novalurin N)and the study group(n=40,Noval-urin R+Dieter's insulin)according to random order table method.The treatment effect,blood glucose levels(fasting blood glucose,2-hour postprandial blood glucose)and complications were compared between the two groups.Results The hospitalization time,urinary ketone body elimination time and blood pH recovery time in the study group were sig-nificantly lower than those in the conventional group,and the differences were statistically significant(all P<0.05).Af-ter treatment,fasting blood glucose and 2-hour postprandial blood glucose levels in two groups were decreased com-pared with those before treatment,and those in the study group were lower than the conventional group,and the differ-ences were statistically significant(both P<0.05).The total incidence of complications in the study group(2.50%)was lower than that in the conventional group(20.00%),and the difference was statistically significant(χ^(2)=4.507,P<0.05).Conclusion The application of Novolin R combined with Dieter's insulin to pediatric diabetic children whose first symptom is ketoacidosis has a better clinical therapeutic effect and reduces the children's blood glucose level and the incidence of complications.