研究中西医结合治疗对慢阻肺稳定期患者肺功能指标的影响

Study on the Influence of Combination of Traditional Chinese and Western Medicine on Pulmonary Function Indexes in Stable Stage COPD Patients

目的分析中西医结合治疗对慢性阻塞性肺疾病(简称慢阻肺)稳定期患者肺功能指标的改善效果。方法回顾性选取2021年1月—2023年12月十堰市郧阳区中医医院收治的80例慢阻肺稳定期患者的临床资料,根据治疗方式的不同分为两组,每组40例。对照组给予西医治疗,研究组给予中西医结合治疗,比较两组肺功能指标、6 min步行试验距离、呼吸困难评分、炎症指标水平。结果治疗后,研究组最大肺活量、1秒钟用力呼气量、1秒率、呼气峰值流速均大于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组6 min步行试验(477.25±33.51)m距离大于对照组(422.94±33.56)m,呼吸困难评分(0.80±0.21)分小于对照组(1.45±0.22)分,差异有统计学意义(t=7.242、13.516,P均<0.05)。研究组治疗后肿瘤坏死因子-α、白介素-8水平小于对照组,差异有统计学意义(P均<0.05)。结论针对慢阻肺稳定期患者提供中西医结合治疗可以显著改善肺功能指标,降低炎症指标。

Objective To analyze the improvement effect of integrated Chinese and Western Medicine on pulmonary function indexes of patients with chronic obstructive pulmonary disease(COPD)in stable stage.Methods Clinical data of 80 patients with stable stage COPD treated in Shiyan Yunyang District Hospital of Traditional Chinese Medicine from January 2021 to December 2023 were retrospectively selected and divided into two groups according to different treatment methods,with 40 cases in each group.The control group was given Western medicine treatment,and the study group was given integrated Chinese and Western medicine treatment.The pulmonary function indexes,6-min walking test distance,dyspnea score and inflammation indexes of the two groups were compared.Result After treatment,the maximum vital capacity,forced expiratory volume in 1 second,forced expiratory volume in one second/forced vital capacity and peak expiratory flow rate in the study group were higher than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the 6-min walking distance of the study group(477.25±33.51)m was greater than that of the control group(422.94±33.56)m,the dyspnea score of the study group(0.80±0.21)points was smaller than that of the control group(1.45±0.22)points,and the differences were statistically significant(t=7.242,13.516,both P<0.05).The levels of tumor necrosis factor-αand interleukin-8 in the study group were lower than those in the control group after treatment,and the differences were statistically significant(both P<0.05).Conclusion The combination of Chinese and Western Medicine treatment for stable stage COPD patients can significantly improve lung function indexes and reduce inflammation indexes.