干扰素联合胸腺肽和苦参素治疗慢性乙型肝炎的疗效

Efficacy of Interferon Combined with Thymosin and Oxymatrine in the Treatment of Chronic Hepatitis B

目的探讨干扰素联合胸腺肽和苦参素治疗慢性乙型肝炎的效果。方法随机选取2020年1月—2022年1月苏州市第五人民医院收治的60例慢性乙型肝炎患者作为研究对象,采用随机数表法分为对照组和观察组,各30例。对照组应用干扰素治疗,观察组应用干扰素联合胸腺肽和苦参素治疗,比较两组的肝功能、免疫功能以及乙肝表面抗原定量。结果治疗后,观察组天冬氨酸转氨酶、丙氨酸氨基转移酶、总胆红素指标水平均低于对照组,差异有统计学意义(P均<0.05);观察组CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,CD8^(+)低于对照组,差异有统计学意义(P均<0.05)。观察组乙肝表面抗原定量为(1215.76±23.54)U/mL,低于对照组的(1854.28±117.06)U/mL,差异有统计学意义(t=29.290,P<0.05)。结论干扰素联合胸腺肽和苦参素治疗慢性乙型肝炎可改善患者肝功能并且还可起到免疫调节作用,利于提高患者康复效果。

Objective To investigate the efficacy of interferon combined with thymosin and oxymatrine in the treatment of chronic hepatitis B.Methods A total of 60 patients with chronic hepatitis B in the outpatient department of Suzhou Fifth People's Hospital from January 2020 to January 2022 were randomly selected as the study objects and divided into control group and observation group,with 30 cases in each group by random number table method.The control group was treated with interferon,the observation group was treated with interferon combined with thymosin and matrine,and the liver function,immune function and HBV surface antigen quantitation were compared between the two groups.Results After treatment,the levels of aspartate aminotransferase,alanine aminotransferase and total bilirubin in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).CD4^(+)and CD4^(+)/CD8^(+)in observation group were higher than those in control group,and CD8^(+)was lower than those in control group,the differences were statistical significance(all P<0.05).The amount of HBSAg in the observation group(1215.76±23.54)U/mL was lower than that in the control group(1854.28±117.06)U/mL,and the difference was statistically significant(t=29.290,P<0.05).Conclusion Interferon combined with thymosin and oxymatrine in the treatment of chronic hepatitis B can improve the liver function of patients and also play an immunomodulatory role,and is conducive to improving the recovery of patients.