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异甘草酸镁联合丁二磺酸腺苷蛋氨酸对经导管肝动脉化疗栓塞术后肝功能损伤的疗效

The Therapeutic Effect of Magnesium Isoglycyrrhizinate Combined with Ademetionine 1,4-Butanedisulfonate on Liver Function Damage after Transcatheter Hepatic Artery Chemoembolization
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摘要 目的:探讨异甘草酸镁(MI)联合丁二磺酸腺苷蛋氨酸(SAM)在经导管肝动脉化疗栓塞(TACE)术后肝功能损伤患者中的治疗效果。方法:选取2021年4月—2023年4月兖矿新里程总医院收治的94例TACE术后肝损伤患者,按随机数字表法将患者分为两组,各47例。对照组采取MI治疗,观察组采取MI联合SAM治疗,持续治疗2周。对比两组临床效果、肝功能指标、血清学指标、生存质量及不良反应发生率。结果:观察组治疗总有效率为93.62%,高于对照组的78.72%(P<0.05)。治疗前,两组肝功能指标、血清学指标及生存质量比较,差异均无统计学意义(P>0.05);治疗后,观察组谷草转氨酶(AST)为(51.63±5.24)U/L、谷丙转氨酶(ALT)为(60.28±7.01)U/L、γ-谷氨酰转肽酶(GGT)为(61.32±7.93)U/L、总胆红素(TBIL)为(23.54±3.56)μmol/L、肿瘤坏死因子-α(TNF-α)为(3.26±0.38)ng/L、白介素-6(IL-6)为(31.14±7.55)pg/mL、超敏C反应蛋白(hs-CRP)为(2.55±0.45)mg/L,均低于对照组的(62.73±6.39)U/L、(72.90±9.28)U/L、(72.46±9.54)U/L、(29.48±5.41)μmol/L、(3.82±0.59)ng/L、(46.69±6.04)pg/mL、(3.57±0.58)mg/L;生活质量综合评定问卷(GQOLI-74)中的生理领域评分(76.46±5.24)分、心理领域评分(75.17±4.73)分、社会领域评分(74.53±6.61)分、环境领域评分(76.25±5.25)分,均高于对照组的(70.37±5.12)、(69.15±5.35)、(66.71±5.80)、(70.03±4.59)分(P<0.05)。两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论:MI联合SAM能改善TACE术后肝损伤患者肝功能,促进血清学指标复常,提升患者生存质量,安全可靠。 Objective:To explore the therapeutic effect of Magnesium Isoglycyrrhizinate(MI)combined with Ademetionine 1,4-Butanedisulfonate(SAM)in patients with liver function damage after transcatheter hepatic artery chemoembolization(TACE).Method:A total of 94 patients with liver injury after TACE surgery admitted to Yankuang New Journey General Hospital from April 2021 to April 2023 were selected and divided into two groups by random number table method,with 47 cases in each group.The control group was treated with MI,while the observation group was treated with SAM for two weeks.The clinical efficacy,liver function indicators,serological indicators,quality of life,and incidence of adverse reactions between two groups were compared.Result:The total effective rate of the observation group was 93.62%,which was higher than 78.72%in the control group(P<0.05).Before treatment,there were no statistically significant differences in liver function indicators,serological indicators,and quality of life between the two groups(P>0.05);after treatment,aspartate aminotransferase(AST)was(51.63±5.24)U/L,alanine aminotransferase(ALT)was(60.28±7.01)U/L,glutamyl transpeptidase(GGT)was(61.32±7.93)U/L,and total bilirubin(TBIL)was(23.54±3.56)μmol/L,tumor necrosis factor-α(TNF-α)was(3.26±0.38)ng/L,interleukin-6(IL-6)was(31.14±7.55)pg/mL,and hypersensitive C reactive protein(hs-CRP)was(2.55±0.45)mg/L in the observation group,which were lower than(62.73±6.39)U/L,(72.90±9.28)U/L,(72.46±9.54)U/L,and(29.48±5.41)μmol/L,(3.82±0.59)ng/L,(46.69±6.04)ng/L,(3.57±0.58)mg/L in the control group;the physiological domain score(76.46±5.24)points,psychological domain score(75.17±4.73)points,social domain score(74.53±6.61)points,and environmental domain score(76.25±5.25)points in the GQOLI-74 questionnaire,which were higher than(70.37±5.12),(69.15±5.35),(66.71±5.80),and(70.03±4.59)points in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of MI and SAM can improve liver function in patients with liver injury after TACE,promote the normalization of serum indicators,improve the quality of life of patients,and is safe and reliable.
作者 谈帅 TAN Shuai(Hepatobiliary Department,Yankuang New Journey General Hospital,Zoucheng 273500,China)
出处 《中国医学创新》 CAS 2024年第16期107-110,共4页 Medical Innovation of China
关键词 经导管肝动脉化疗栓塞 异甘草酸镁 丁二磺酸腺苷蛋氨酸 肝损伤 不良反应 Transcatheter hepatic artery chemoembolization Magnesium Isoglycyrrhizinate Ademetionine1,4-Butanedisulfonate Liver injury Adverse reactions
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