芪桂五物汤对支气管哮喘患者症状改善、气道重塑及免疫平衡的影响

The Effect of Qigui Wuwu Decoction on Symptom Improvement,Airway Remodeling and Immune Balance in Patients with Bronchial Asthma

目的:观察并探讨芪桂五物汤对支气管哮喘患者症状改善、气道重塑及免疫平衡的影响。方法:选取2021年10月—2023年3月太仓市中医医院收治的80例支气管哮喘患者,按照单双数抽签法将其平均分为两组,即对照组(40例)和观察组(40例)。入院后,对照组给予常规方法治疗,观察组除常规治疗外再给予芪桂五物汤治疗。比较两组治疗效果、气道重塑指标、血清免疫因子水平及肺通气功能指标。结果:观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组气道重塑指标比较,差异均无统计学意义(P>0.05);治疗后,两组的气道重塑指标水平均较治疗前有降低,相较于对照组,观察组降低更为显著(P<0.05)。治疗前,两组血清免疫因子水平比较,差异均无统计学意义(P>0.05);治疗后,两组γ干扰素(IFN-γ)、白介素-4(IL-4)均较治疗前有所改善,相较于对照组,观察组改善更为显著(P<0.05)。治疗前,两组肺通气功能指标比较,差异均无统计学意义(P>0.05);治疗后,两组肺通气功能指标水平均较治疗前有所提高,相较于对照组,观察组提高更为显著(P<0.05)。结论:芪桂五物汤不仅可以明显改善支气管哮喘患者的临床症状,还能改善患者的气道重塑、血清免疫因子水平及肺功能指标,对支气管哮喘患者的治疗效果显著。

Objective:To observe and explore the effects of Qigui Wuwu Decoction on symptom improvement,airway remodeling and immune balance in patients with bronchial asthma.Method:A total of 80 patients with bronchial asthma admitted to Taicang Traditional Chinese Medicine Hospital from October 2021 to March 2023 were selected and divided into control group(40 cases)and observation group(40 cases)according to odd-even number drawing method.After admission,the control group was treated with conventional methods,while the observation group was treated with Qigui Wuwu Decoction in addition to conventional treatment.The therapeutic effects,airway remodeling indexes,serum immune factor levels and lung ventilation function indicators were compared between the two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in airway remodeling indexes between the two groups(P>0.05);after treatment,the levels of airway remodeling indexes in the two groups were lower than those before treatment,compared with the control group,those in the observation group were decreased more significantly(P<0.05).Before treatment,there were no statistically significant differences in the levels of serum immune factors between the two groups(P>0.05);after treatment,the levels of interferon-γ(IFN-γ)and interleukin-4(IL-4)in the two groups were improved compared with those before treatment,compared to those in the control group,those in the observation group were improved more significantly(P<0.05).Before treatment,there were no statistically significant differences in lung ventilation function indicators between the two groups(P>0.05);after treatment,the levels of lung ventilation function indicators in both groups were improved compared to those before treatment,compared to those in the control group,those in the observation group were improved more significantly(P<0.05).Conclusion:Qigui Wuwu Decoction can not only significantly improve the clinical symptoms of patients with bronchial asthma,but also improve airway remodeling,serum immune factor levels and lung function indicators.It has a significant therapeutic effect on patients with bronchial asthma.