贝伐珠单抗结合TC化疗方案治疗卵巢癌的临床效果及对血清炎症因子、肿瘤标志物的影响

Clinical Effect of Bevacizumab Combined with TC Chemotherapy Regimen in the Treatment of Ovarian Carcinoma and Its Influence on Serum Inflammatory Factors and Tumor Markers

目的:探讨在卵巢癌的临床治疗中采用贝伐珠单抗结合TC化疗方案的效果及对血清炎症因子、肿瘤标志物的影响。方法:选择2018年4月—2020年4月于当阳市人民医院肿瘤科进行治疗的92例卵巢癌患者,用随机数字表法分为对照组(n=46)、观察组(n=46)。对照组予以常规TC化疗方案治疗,观察组在对照组基础上结合贝伐珠单抗治疗。比较两组生存率、肿瘤标志物水平和血清炎症因子水平。结果:观察组1、3年生存率均高于对照组(P<0.05);治疗后,观察组癌胚抗原(CEA)、糖类抗原125(CA125)和神经元特异性烯醇化酶(NSE)水平均较对照组低(P<0.05);治疗后,观察组C反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平均低于对照组(P<0.05)。结论:在卵巢癌的治疗中采取贝伐珠单抗结合TC化疗方案的临床效果较好,可有效提高患者生存率,改善肿瘤标志物水平,降低血清炎症因子水平。

Objective:To explore the effect of of Bevacizumab combined with TC chemotherapy regimen in the clinical treatment of ovarian carcinoma and its influence on serum inflammatory factors and tumor markers.Method:A total of 92 patients with ovarian carcinoma treated in Department of Oncology,Dangyang People's Hospital from April 2018 to April 2020 were selected and divided into control group(n=46)and observation group(n=46)by random number table method.The control group was treated with conventional TC chemotherapy regimen,and the observation group was treated with Bevacizumab based on the control group.The survival rate,recurrence rate,tumor markers levels and serum inflammatory factors levels were compared between the two groups.Result:The 1-year and 3-year survival rates of observation group were higher than those of control group(P<0.05).After treatment,the levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and neuron specific enolase(NSE)in observation group were lower than those in control group(P<0.05).After treatment,the levels of C reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in observation group were lower than those in control group(P<0.05).Conclusion:In the treatment of ovarian carcinoma,Bevacizumab combined with TC chemotherapy regimen has good clinical effect,which can effectively improve the survival rate of patients,improve the levels of tumor markers,and reduce the levels of serum inflammatory factors.