温经汤联合揿针治疗虚寒证月经后期的效果

Effect of Wenjing Decoction Combined with Press-needle in Treating Delayed Menstruation of Deficiency-cold Syndrome

目的:探讨温经汤联合揿针对虚寒证月经后期的治疗效果。方法:选取2020年1—12月江西省妇幼保健院收治的160例虚寒证月经后期患者作为研究对象。根据随机数字表法分为研究组、A组、B组和C组,每组40例。研究组采取温经汤联合揿针进行治疗,A组给予患者服用温经汤,B组采用揿针治疗,C组采用西药激素疗法。比较四组临床效果,子宫血流动力学指标[收缩期峰值流速(PSV)、阻力指数(RI)、搏动指数(PI)],雌激素(卵泡刺激素、黄体生成素和雌二醇),复发率及不良反应(肝功能异常、恶心呕吐、皮疹、肾功能损伤)发生情况。结果:研究组总有效率为97.50%,高于A组、B组、C组(P<0.05),A组、B组、C组之间治疗总有效率比较,差异均无统计学意义(P>0.05)。治疗后,四组RI、PI水平及卵泡刺激素、黄体生成素水平均较治疗前有所下降,且研究组均低于A组、B组、C组(P<0.05),四组PSV水平和雌二醇水平均较治疗前有所升高,且研究组均高于A组、B组、C组,差异均有统计学意义(P<0.05),治疗后,A组、B组、C组的子宫血流动力学指标及雌激素水平比较,差异均无统计学意义(P>0.05)。治疗结束后3个月随访,研究组复发率低于A组、B组、C组,差异均有统计学意义(P<0.05)。研究组不良反应总发生率与A组、B组、C组比较,差异均无统计学意义(P>0.05)。结论:温经汤联合揿针能够有效治疗虚寒证月经后期,改善子宫血流动力学和血清雌激素水平,降低复发的可能性,安全性良好。

Objective:To explore the therapeutic effect of Wenjing Decoction combined with pressneedle in the treatment of delayed menstruation of deficiency-cold syndrome.Method:A total of 160 patients with deficiency-cold syndrome of delayed menstruation from January to December 2020 in Jiangxi Maternal and Child Health Hospital were selected as the study subjects,they were divided into study group,group A,group B and group C by random number table method,with 40 cases in each group.The study group was treated with Wenjing Decoction combined with press-needle,group A was given Wenjing Decoction,group B performed press-needle,and group C was treated with western medicine hormone therapy.The clinical efficacy,uterine hemodynamic parameters[peak systolic velocity(PSV),resistance index(RI),pulsatility index(PI)],estrogens(follicle stimulating hormone,luteinizing hormone and estradiol),recurrence rate and the incidence of adverse reactions(abnormal liver function,nausea and vomiting,rash,renal function injury)were compared among the four groups.Result:The total effective rate in study group(97.50%)was higher than that in group A,group B and group C(P<0.05).There were no statistical significance differences in the total effective rate of treatment among group A,group B and group C(P>0.05).After treatment,the RI,PI,follicle stimulating hormone and luteinizing hormone were decreased in the four groups compared to before treatment,and those in study group were lower than those in group A,group B and group C(P<0.05);the PSV and estradiol were increased in the four groups compared to before treatment,and those in study group were higher those in group A,group B and group C(P<0.05);after treatment,the uterine hemodynamic parameters and estrogens in group A,group B and group C were no statistically significant differences(P>0.05).At 3 months of follow-up after the end of treatment,the recurrence rate in study group was lower than that in group A,group B and group C,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in study group compared that in group A,group B and group C,the differences were statistically significant(P>0.05).Conclusion:Wenjing Decoction combined with press-needle can effectively treat the deficiency-cold syndrome of delayed menstruation,improve the uterine hemodynamics and serum estrogens levels,and reduce the possibility of recurrence,with good safety.