硝苯地平联合拉贝洛尔对子痫前期患者胎盘血流灌注的影响

Influence of Nifedipine Combined with Labetalol for Placental Blood Perfusion of Patients with Preeclampsia

目的:探究硝苯地平联合拉贝洛尔在子痫前期患者中的疾病控制效果、安全性,并观察其对胎盘血流灌注的影响。方法:将2018年1月—2023年8月荆门市中医医院的82例子痫前期患者根据随机数字表法分为两组,每组41例。对照组采用拉贝洛尔进行治疗,观察组则采用硝苯地平联合拉贝洛尔进行治疗。比较两组治疗效果、不良反应发生率、治疗前后的血管收缩舒张因子[内皮素-1(ET-1)、一氧化氮(NO)]及胎盘血流灌注指标[血管化指数(VI)、血流指数(FI)及血管化-血流指数(VFI)]。结果:观察组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。两组的各类不良反应发生率比较,差异均无统计学意义(P>0.05)。治疗前,两组的血管收缩舒张因子及胎盘血流灌注指标比较,差异均无统计学意义(P>0.05);治疗15 d及30 d后,两组的ET-1指标均较治疗前降低,且观察组ET-1均低于对照组,两组的NO及胎盘血流灌注指标均较治疗前升高,且观察组NO及胎盘血流灌注指标均高于对照组,差异均有统计学意义(P<0.05)。结论:硝苯地平与拉贝洛尔联合应用在子痫前期患者中的应用效果较好,可显著改善患者胎盘血流灌注状态。

Objective:To investigate the disease control effect and safety of Nifedipine combined with Labetalol of patients with preeclampsia,and observe the influence for and placental blood perfusion.Method:A total of 82 patients with preeclampsia in Jingmen Traditional Chinese Medicine Hospital from January 2018 to August 2023 were divided into two groups by the random number table,with 41 cases in each group.The control group were treated with Labetalol,the observation group were treated with Nifedipine combined with Labetalol.Then the treatment effect,adverse reaction rates,vasoconstriction and vasodilation factors[endothelin-1(ET-1),nitric oxide(NO)]and placental blood perfusion indexes[vascularization index(VI),flow index(FI)and vascularizationflow index(VFI)]before and after the treatment of two groups were compared.Result:The total effective rate of observation group was significantly higher than that of control group,the difference was statistically significant(P<0.05).There were no significant differences in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there were no significant differences in vasoconstriction and relaxation factor and placental blood perfusion index between the two groups(P>0.05);after 15 and 30 days of treatment,the ET-1 of the two groups were lower than those before treatment,and the ET-1 of the observation group were lower than those of the control group,placental blood perfusion indexes in the two groups were higher than those before treatment,and placental blood perfusion indexes in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The application effect of Nifedipine combined with Labetalol in patients with preeclampsia is better,and it can significantly improve the placental blood perfusion of patients.