不同预后及严重程度的创伤性颅脑损伤患者T淋巴细胞亚群和CRP水平分析

Analysis of T Lymphocyte Subsets and CRP Levels in Traumatic Brain Injury Patients with Different Prognoses and Severity Degrees

目的:旨在研究不同预后及严重程度的创伤性颅脑损伤(TBI)患者T淋巴细胞亚群和CRP水平分析。方法:回顾性分析宜春新建医院2022年5月—2023年6月收治的100例创伤性颅脑损伤患者临床数据。根据患者入院时格拉斯哥昏迷量表(Glasgow coma scale,GCS)评分将其分为三组,轻型组(25例):GCS评分13~15分;中型组(33例):GCS评分9~12分;重型组(42例):GCS评分为3~8分,选取同期体检正常志愿者100例为对照组。根据TBI预后存活情况分为存活组90例、死亡组10例,观察并比较不同组别患者的T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、C反应蛋白(CRP),并分析各指标之间的相关性。结果:不同颅脑损伤组血清CD8^(+)、CRP水平均高于对照组,CD4^(+)、CD3^(+)水平及CD4^(+)/CD8^(+)均低于对照组(P<0.05);重型组、中型组CD8^(+)水平均高于轻型组,CD4^(+)、CD3^(+)水平及CD4^(+)/CD8^(+)均低于轻型组(P<0.05);重型组CD8^(+)水平高于中型组,CD4^(+)、CD3^(+)水平及CD4^(+)/CD8^(+)均低于中型组(P<0.05);重型组CRP水平高于中型组和轻型组,中型组高于轻型组(P<0.05)。存活组CD4^(+)、CD4^(+)/CD8^(+)均较死亡组高,CD8^(+)、CPR均低(P<0.05)。根据Pearson统计分析显示,TBI患者的CRP与CD4^(+)、CD3^(+)、CD4^(+)/CD8^(+)均呈负相关,CRP与CD8^(+)呈正相关(P<0.05)。结论:不同预后及严重程度的创伤性颅脑损伤患者中,CRP水平与CD8^(+)呈正相关,与CD4^(+)、CD3^(+)及CD4^(+)/CD8^(+)均呈负相关,且严重程度越高CRP水平越高,CD4^(+)、CD3^(+)及CD4^(+)/CD8^(+)水平越低。

Objective:To investigate the analysis of T lymphocyte subsets and C reactive protein(CRP)levels in traumatic brain injury(TBI)patients with different prognoses and severity degrees.Method:The clinical data of 100 patients with TBI admitted to Yichun Xinjian Hospital from May 2022 to June 2023 were restrospectively analyzed.The patients were divided into three groups based on their Glasgow coma scale(GCS)scores at the time of admission,mild group(25 patients):GCS score 13-15 points;moderate group(33 patients):GCS score 9-12 points;severe group(42 patients):GCS score 3-8 points,a control group consisted of 100 healthy volunteers examined during the same period.According to the prognosis of TBI,patients were further divided into a survival group(90 patients)and a death group(10 patients).The T lymphocyte subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))and CRP levels were observed and compared across different groups,and the correlations among these indicators were analyzed.Result:Serum CD8^(+)and CRP levels in different TBI groups were higher than those in the control group,while CD4^(+),CD3^(+),and CD4^(+)/CD8^(+)were lower than those in the control group(P<0.05);CD8^(+)levels in the severe group and moderate group were higher than that in the mild group,and CD4^(+),CD3^(+)and CD4^(+)/CD8^(+)were lower than those in the control group(P<0.05);CD8^(+)level in the severe group was higher than that in the moderate group,and CD4^(+),CD3^(+)and CD4^(+)/CD8^(+)were lower than those in the moderate group(P<0.05);the CRP level in the severe group was higher than that in the moderate group and mild group,and that in the moderate group was higher than that in the mild group(P<0.05).CD4^(+),CD4^(+)/CD8^(+)in the survival group were higher than those in the death group,and CD8^(+),CRP were lower than those in the death group(P<0.05).According to Pearson statistical analysis,in patients with different degrees of severity,CRP level showed a negative correlation with CD4^(+),CD3^(+),and the CD4^(+)/CD8^(+),while a positive correlation with CD8^(+)levels(P<0.05).Conclusion:In patients with TBI of different prognoses and severity,CRP levels are positively correlated with CD8^(+),and negatively correlated with CD4^(+),CD3^(+),and CD4^(+)/CD8^(+).Additionally,the higher the severity,the higher the CRP levels,while CD4^(+),CD3^(+),and CD4^(+)/CD8^(+)levels are lower.