良性前列腺增生患者经尿道前列腺切除术后发生深静脉血栓形成的影响因素分析

Analysis of Influencing Factors of Deep Vein Thrombosis Occurring after Transurethral Resection of Prostate in Patients with Benign Prostatic Hyperplasia

目的:探讨良性前列腺增生(BPH)患者经尿道前列腺切除术(TURP)后发生深静脉血栓形成(DVT)的影响因素。方法:回顾性分析2017年1月—2023年5月济南市第一人民医院收治的588例BPH患者的临床资料,根据术后DVT发生与否,将患者分为DVT组和对照组,DVT组104例,对照组484例。对比分析两组患者的性别、年龄、冠心病史等资料,将组间比较有显著差异的变量代入logistic回归进行多因素分析,筛选TURP后发生DVT的影响因素。结果:DVT组脑梗死病史占比、中性粒细胞计数、中性粒细胞-淋巴细胞比值(NLR)、血小板-淋巴细胞比值(PLR)均高于对照组,淋巴细胞计数、血小板-中性粒细胞比值(PNR)均低于对照组,差异均有统计学意义(P<0.05)。多因素logistic回归分析结果显示,脑梗死史(脑梗死恢复期)、中性粒细胞计数、PNR是BPH患者经尿道前列腺切除术后发生DVT的危险因素(P<0.05)。结论:脑梗死恢复期、较高的中性粒细胞计数和较低的PNR可增加BPH患者经尿道前列腺切除术后发生深静脉血栓形成的风险。

Objective:To explore the influencing factors of deep vein thrombosis(DVT)occurring after transurethral resection of prostate(TURP)in patients with benign prostatic hyperplasia(BPH).Method:The clinical data of 588 patients with BPH admitted to the First People's Hospital of Jinan from January 2017 to May 2023 were retrospectively analyzed.The patients were divided into the DVT group and the control group according to the occurrence or not of postoperative DVT,with 104 cases in the DVT group and 484 cases in the control group.Gender,age,history of coronary heart disease and other information of patients in the two groups were compared and analyzed,and variables with significant differences in comparison between the groups were substituted into logistic regression for multifactorial analysis to screen the influencing factors of the occurrence of DVT after TURP.Result:The percentage of patients in cerebral infarction history,neutrophil count,neutrophil-lymphocyte ratio(NLR),and platelet-lymphocyte ratio(PLR)in the DVT group were higher than those in the control group,while the lymphocyte count and platelet-neutrophil ratio(PNR)were lower than those in the control group,the differences were statistically significant(P<0.05).The results of the multifactorial logistic regression analysis suggested that history of cerebral infarction(recovery period of cerebral infarction),neutrophil count,and PNR were risk factors for DVT after TURP in patients with BPH(P<0.05).Conclusion:Recovery period of cerebral infarction,higher neutrophil counts,and lower PNR increase the risk of DVT after TURP in patients with BPH.