支链氨基酸在运动改善胰岛素抵抗中的作用研究进展

Research progress on the role of branched-chain amino acids in the improvement of insulin resistance by exercise

作为必需氨基酸,支链氨基酸(branched chain amino acids, BCAAs)是一种被广泛应用的运动营养补剂。然而越来越多的证据表明,BCAAs与胰岛素抵抗(insulin resistance, IR)之间密切相关,BCAAs分解代谢能力受损是高水平BCAAs的主要原因。运动是有效预防和缓解IR的非药物手段,急性运动和长期运动可能通过不同的调节因子来增强BCAAs分解代谢以减轻BCAAs堆积,促进BCAAs稳态的恢复。本文将针对运动对BCAAs的作用和可能机制以及运动通过BCAAs改善IR的研究现状进行综述,旨在为IR人群制定运动营养干预策略提供新思路。

Branched chain amino acids(BCAAs)as essential amino acids are popular sports nutrition supplements.However,an increasing amount of evidence suggests that BCAAs are strongly associated with insulin resistance(IR),and impaired BCAAs catabolism is an important contributor to high levels of BCAAs.Exercise is an effective non-pharmacological approach to the prevention and alleviation of metabolic diseases.Acute and long-term exercise participate in exercise-enhanced BCAAs catabolism to attenuate BCAAs accumulation and promote the recovery of BCAAs homeostasis through various regulatory factors,respectively.This review summarizes the current state of research on the effects and possible mechanisms of exercise-mediated BCAAs,as well as exercise amelioration of IR through BCAAs,with the aim of providing new ideas for the development of sports nutrition intervention strategies for the IR population.