1993—2022年恶性疟原虫RIFIN蛋白研究文献计量学分析

Bibliometric analysis of researches on the Plasmodium falciparum repetitive interspersed families of polypeptides protein from 1993 to 2022

目的 对1993—2022年恶性疟原虫重复散布蛋白家族(repetitive interspersed families of polypeptides,RIFIN)研究文献进行文献计量学分析,总结研究热点,为RIFIN蛋白后续研究提供参考。方法 在Web of Science核心合集数据库中检索1993—2022年RIFIN蛋白研究相关论文,采用Cite Space 6.2.4.0软件分析1993—2022年各年发文量并构建国家、作者、机构合作网络图谱;提取文献的关键词绘制关键词共现、聚类、突现和时间线图谱,分析RIFIN蛋白研究热点。结果 共纳入745篇英文文献进行文献计量学分析,1993—2022年年发文量为18~36篇。RIFIN蛋白研究领域活跃度居前3位的国家为美国、英国、法国,活跃度较高的机构是高校和研究机构,未发现活跃度特别高的作者。关键词共形成重复DNA序列、分子流行病学、抗原变异等3个聚类。关键词共现、突现和时间线分析结果显示,既往RIFIN蛋白研究主要集中在基因性质、功能等方面,涉及的关键词包括重复DNA序列、进化等;近年来研究热点转向基因多样性和免疫反应等方面,涉及的关键词包括基因多样性、抗原变异、结合等。结论 1993—2022年RIFIN蛋白研究相关论文逐年发文量相对稳定,本研究结果可望为RIFIN蛋白后续研究提供借鉴。

Objective To perform a bibliometric analysis of researches on the Plasmodium falciparum repetitive interspersed families of polypeptides(RIFIN)protein from 1993 to 2022 and identify the hot topics in the RIFIN protein research,so as to provide insights into future researches on RIFIN protein.Methods RIFIN protein-associated publications were retrieved in the Web of Science Core Collection from 1993 to 2022 and all bibliometric analyses were performed using the software CiteSpace 6.2.4.0.The annual number of RIFIN protein-associated publications was analyzed from 1993 to 2022,and country,author and institution collaboration networks were created.Keywords were extracted from RIFIN protein-associated publications for plotting keyword co-occurrence,clustering,burst and timeline maps to identify the hot topics in the RIFIN protein research.Results A total of 745 English RIFIN protein-associated publications were included in the final bibliometric analysis,and there were 18 to 36 publications each year from 1993 to 2022.The top three countries with the highest activity in the RIFIN protein research included the United States,the United Kingdom and France,universities and research institutes were highly active in the RIFIN protein research;however,no authors were identified with a high activity in the RIFIN protein research.There were three keyword clusters in the RIFIN protein-associated publications,including repetitive DNA sequence,molecular epidemiology and antigenic variation.Keyword co-occurrence,burst and timeline analyses showed that previous RIFIN protein-associated publications mainly focused on gene properties and functions,involving keywords of repetitive DNA sequence and evolution,and recent hot topics for the RIFIN protein research shifted to genetic diversity and immune response,involving keywords of genetic diversity,antigenic variation and binding.Conclusions The annual number of RIFIN protein-associated publications was relatively stable from 1993 to 2022.This bibliometric analysis may provide insights into future researches on the RIFIN protein.