社交隔离调控本能行为的神经机制研究进展

Research progress on the neural mechanism of the regulation of social isolation on innate behaviors

本能行为主要受遗传控制,但也受到社交隔离等社交经历的调控。在果蝇和小鼠等模式动物的研究中已经发现社交隔离可以引起激素、神经递质、神经肽等分子水平以及神经环路层面的变化,进而调控动物的本能行为。本文主要对社交隔离通过改变物种保守的神经肽和神经递质的表达进而调控动物睡眠、生殖行为、攻击行为等本能行为的最新进展进行综述,以期深化理解社交隔离调控本能行为的关键且保守的信号通路。

Innate behavior is mainly controlled by genetics,but is also regulated by social experiences such as social isolation.Studies in animal models such as Drosophila and mice have found that social isolation can regulate innate behaviors through the changes at the molecular level,such as hormone,neurotransmitter,neuropeptide level,and at the level of neural circuits.In this review,we summarized the research progress on the regulation of social isolation on various animal innate behaviors,such as sleep,reproduction and aggression by altering the expression of conserved neuropeptides and neurotransmitters,hoping to deepen the understanding of the key and conserved signal pathways that regulate innate behavior by social isolation.