原发性闭角型青光眼患者虹膜的动态变化

Research progress on dynamic changes of iris in patients with primary angle closure glaucoma

原发性闭角型青光眼(primary angle-closure glaucoma,PACG)是一类具有类似解剖结构特征(前房较浅、角膜相对较小、晶状体相对较厚、眼轴较短等)的青光眼,发病原因共同特征是前房角的急性或慢性关闭,使房水流出受阻,眼压增高,导致视功能损害。虹膜组织结构在发病过程中起着重要作用。以往研究大多聚焦于虹膜静态解剖结构特点,然而,并非所有具有相似解剖特征的可疑原发房角关闭(primary angle-closure suspect,PACS)个体都会发展为PACG。随着眼前段成像技术的发展,近年来研究发现PACG患者虹膜组织结构、动态变化、生物力学特性以及自主神经功能等方面存在异常,虹膜动态变化异常在PACG的早期筛查以及PACS病情进展预测方面发挥重要作用,为PACG的早期诊断和干预提供参考。

Primary angle-closure glaucoma(PACG)is a kind of glaucoma with similar anatomical structure characteristics(shallow anterior chamber,relatively small cornea,relatively thick lens,short axial length,etc.).The common cause of PACG is acute or chronic closure of the anterior chamber angle,which hinders the outflow of aqueous humor,increases intraocular pressure,and leads to visual impairment.Iris tissue structure plays an important role in the pathogenesis.Previous studies have mostly focused on the characteristics of iris static anatomy.However,not all suspected primary angle closure(PACS)individuals with similar anatomical features will develop into PACG.With the development of anterior segment imaging technology,recent studies have found the abnormal iris dynamic changes,such as the iris tissue structure,dynamic changes,biomechanical properties and autonomic nerve function,etc.,play the important roles on the early screening of PACG and the prediction of PACS disease progression.