铁死亡在白内障发生机制中的作用

Roles of ferroptosis in the pathogenesis of cataract

既往研究表明,发生白内障的晶状体具有铁死亡特点,如氧化活性铁含量升高、脂质过氧化水平升高、谷胱甘肽过氧化物酶系统失衡。最新的研究则证实年龄相关性白内障的晶状体上皮细胞发生了铁死亡,应用虾青素、褪黑素等药物可以通过抑制铁死亡通路延缓白内障的形成。此外,高度近视并发性白内障中的脂质过氧化水平、氧化活性铁水平比年龄相关性白内障更高。

Previous studies have shown that cataractous lenses exhibit characteristics of ferroptosis,including increased levels of oxidatively active iron,elevated lipid peroxidation,and a disrupted glutathione peroxidase system.Recent researches have confirmed that epithelial cells from age-related cataract lenses underwent ferroptosis.The use of agents like astaxanthin and melatonin can delay cataract formation by inhibiting the ferroptosis pathway.Additionally,the levels of lipid peroxidation and oxidative active iron in high myopia-associated cataracts have been found to be higher than those in age-related cataracts.