冰片的促渗透作用机制及其在眼病治疗中的潜在应用

Mechanism of borneol promoting permeability and its potential application in treatment of eye diseases

冰片是一种小分子脂溶性萜类物质,对亲水性和分子量大的药物具有良好的选择性促渗透作用,通过改变皮肤角质层、疏松内皮细胞间的紧密连接结构以促进渗透。冰片亦能在生理性眼组织和(或)病变组织发挥良好的促渗透作用,即通过疏松角膜上皮细胞使磷脂双分子层排列有序,扩大细胞间隙进而促渗。此外还可调节视网膜血管内皮细胞及紧密连接蛋白在血-眼屏障、角膜屏障及视网膜屏障中发挥促渗透作用,并能促进多种治疗眼病的药物更好地发挥疗效。

Borneol,a lipid-soluble terpenoid,which has a good selective permeation enhancement effect on hydrophilic and high molecular weight drugs by changing the tight junction structure between skin stratum corneum and loose endothelial cells.Additionally,borneol positively impacts the penetration of drugs in physiological eye tissue and pathological lesion tissues.It accomplishes this by loosening corneal epithelial cells,enabling the phospholipid bilayer to arrange in an orderly way and expanding the intercellular space,thus promoting infiltration and channel induction.Furthermore,borneol has the ability to regulate retinal vascular endothelial cells and tight junction proteins within the blood-eye barrier,corneal barrier,and retinal barrier.This modulation can enhance the therapeutic effects of various drugs used in the treatment of ocular diseases.