类器官在肿瘤放射治疗相关研究中的应用进展

Advances in application of organoids to research on radiotherapy of tumors

类器官是一种体外培养的三维微型结构,源自健康个体或患者的人多能干细胞或成体干细胞。相对于传统的细胞系或动物模型,类器官被视为更有前途的高保真模型,在疾病建模、药物开发、建立活体生物库和探索个性化治疗方面具有独特的优势。近年来,类器官技术的飞速发展为革新肿瘤临床前实验模型和推动临床个性化诊疗带来了新希望。本综述旨在介绍类器官在肿瘤放射治疗领域的发展现状和最新进展,讨论癌症类器官模型的优势和局限,并对其在放射治疗领域的应用前景进行展望。

Organoids are in vitro⁃cultured three⁃dimensional(3D)miniature structures derived from human pluripotent stem cells or adult stem cells from healthy individuals or patients.Compared to traditional two⁃dimensional(2D)cell lines or animal models,organoids are regarded as more promising high⁃fidelity models,possessing unique advantages in terms of disease modeling,drug development,the establishment of living biobanks,and the exploration of personalized treatment.Over recent years,the rapid development of organoid technology has brought new hopes for innovating preclinical experimental tumor models and promoting clinical personalized diagnosis and treatment.This review is intended to introduce the development status and latest progress of organoids in the field of radiotherapy for tumors,explore the advantages and limitations of organoid models for cancer,and prospect for its application in the field of radiotherapy.