聚(乙二醇)-b-聚(N-己基甘氨酸)两嵌段共聚物的合成及其在乙腈/氯仿混合溶剂里的自组装

Synthesis of Poly(ethylene glycol)-block-poly(N-hexylglycine)Block Polymers and Self-assembly in Acetonitrile/Chloroform Mixture

分子自组装是一种普遍存在于生命体系中的现象,其形成的复杂结构在生物学功能中起着至关重要的作用。聚类肽是一类很有前途的拟肽聚合物,其优良的结构可设计性和可调控的自组装行为可为基础研究和生物技术应用提供独特的性能。通过开环聚合设计合成了具有结晶性能的聚(乙二醇)-b-聚(N-己基甘氨酸)(PEG-b-PNHG)两嵌段共聚物。表征并分析了PEG-b-PNHG的结构和结晶性。在PNHG段结晶驱动的作用下,该聚合物在乙腈/氯仿混合溶剂中自组装得到盘状的胶束聚集体。结合聚类肽良好的生物相容性和结构多样性,所制备的嵌段自组装纳米材料在药物传递、生物工程等领域具有较好的应用价值。

Molecular self-assembly is a ubiquitous phenomenon in living systems.The complex structures formed by molecular self-assembly play an important role in biological functions.Polypeptoids are a promising class of peptidomimetic polymers with highly designable structures and controllable self-assembly,which provide excellent unique properties for both fundamental research and applications in biotechnology.In this paper,a type of diblock polypeptoid poly(ethylene glycol)-block-poly(N-hexylglycine)(PEG-b-PNHG)with good crystallization performance was synthesized via ring-opening polymerization(ROP).The structure and crystallization behaviors of PEG-b-PNHG were characterized and analyzed.The polymer can spontaneously assemble into a plate-like micellar aggregate structure in acetonitrile/chloroform mixture driven by crystallization of PNHG block.In view of the excellent biocompatibility and structural diversity,the obtained assemblies show good applications value in the fields of drug delivery and bioengineering.