摘要
组蛋白去乙酰化酶3(HDAC3)是一种表观遗传修饰酶,参与动脉粥样硬化(As)的发生发展,寻找有效的HDAC3抑制剂对治疗As具有重要意义。本文综述了HDAC3与As的关系、HDAC3抑制剂最新的研究进展以及一些中药通过抑制HDAC3治疗心血管疾病的作用机制,旨在为研发以HDAC3为靶点的抗As药物提供新的思路。
Histone deacetylase 3(HDAC3)is an epigenetic modification enzyme,which participates in the occurrence and development of atherosclerosis(As).It is significant to search for effective HDAC3 inhibitors for the treatment of atherosclerosis.This article reviews the relationship between HDAC3 and atherosclerosis,the latest research progress of HDAC3 inhibitors,and the therapeutic effects of some traditional Chinese medicine on cardiovascular diseases by inhibiting HDAC3.It aims to provide new ideas for developing anti-atherosclerotic drugs targeting HDAC3.
作者
夏子涵
张和
张紫琼
李星仪
王亦宁
王维蓉
XIA Zihan;ZHANG He;ZHANG Ziqiong;LI Xingyi;WANG Yining;WANG Weirong(Department of Laboratory Animal Science,School of Basic Medical Science,Xi'an Jiaotong University,Health Science Center,Xi'an,Shaanxi 710061,China;Institute of Cardiovascular Science,Translational Medicine Institute,Xi'an Jiaotong University,Health Science Center,Xi'an,Shaanxi 710061,China)
出处
《中国动脉硬化杂志》
CAS
2024年第7期621-626,640,共7页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(81873520)
陕西省创新能力支撑计划项目(2023-CX-PT-07)。
关键词
组蛋白去乙酰化酶3
动脉粥样硬化
抑制剂
中药
histone deacetylase 3
atherosclerosis
inhibitors
traditional Chinese medicine
