钙化结节与急性冠脉综合征

Calcified nodule and acute coronary syndrome

动脉粥样硬化病变钙化结节(ACN)是引起冠状动脉血栓形成与急性冠脉综合征(ACS)的少见但重要的原因。爆裂型钙化结节(ECN)是引起心源性猝死的一种病因,其典型表现为突入管腔的成簇的爆裂样钙化碎片伴有纤维帽破裂,表面附着有血栓。ACN相关的ACS预后较差,围手术期心肌梗死、心源性死亡、靶病变再次血运重建等的发生率较高。本文就ACN的研究进展作一综述。

Atherosclerotic calcified nodule is rare but important cause of coronary artery thrombosis and acute coronary syndrome.Eruptive calcified nodule is characterized by clusters of burst like calcified fragments protruding into the lumen accompanied by ruptured fibrous caps and thrombus attached to the surface,which is a potential cause of sudden cardiac death.The prognosis of acute coronary syndrome caused by calcified nodule is poor,and the incidence of perioperative myocardial infarction,cardiac death,and target lesion revascularization is high.This article reviews the progress in the diagnosis and treatment of atherosclerotic calcified nodule in coronary artery.