清开灵颗粒联合磷酸奥司他韦颗粒治疗流行性感冒患儿的效果及对炎症指标的影响

Effect of Qingkailing Granules combined with Oseltamivir Phosphate Granules in the treatment of children with influenza and influence on inflammatory indicators

目的 探讨清开灵颗粒联合磷酸奥司他韦颗粒治疗流行性感冒(流感)患儿的效果及对炎症指标的影响。方法 选取2021年1月至2023年1月兰陵县向城镇卫生院治疗的86例流感患儿作为研究对象,按照随机数字表法分为对照组(n=43)与观察组(n=43)。对照组采用磷酸奥司他韦颗粒治疗,观察组采用清开灵颗粒联合磷酸奥司他韦颗粒治疗。比较两组临床疗效、症状改善时间、炎症指标及不良反应发生情况。结果 观察组治疗总有效率(95.35%)高于对照组(79.07%),差异有统计学意义(P<0.05)。观察组发热改善时间为(1.15±0.14)d、咳嗽改善时间为(1.93±0.28)d、鼻塞改善时间为(1.84±0.77)d,均短于对照组的(2.26±0.17)、(2.21±0.42)、(3.49±1.05)d,差异有统计学意义(P<0.05)。治疗后,观察组C反应蛋白水平为(9.87±2.13)mg/L,γ干扰素水平为(1.38±0.23)μg/L,均低于对照组的(12.98±2.24)g/L、(1.91±0.32)μg/L,差异有统计学意义(P<0.05)。观察组不良反应总发生率(6.98%)低于对照组(23.26%),差异有统计学差异(P<0.05)。结论 流感患儿采用清开灵颗粒联合磷酸奥司他韦颗粒治疗,可有效减轻症状,降低炎症指标及不良反应发生率。

Objective To explore the effect of Qingkailing Granules combined with Oseltamivir Phosphate Granules in the treatment of children with influenza and influence on inflammatory indicators.Methods A total of 86 children with influenza admitted to Xiangcheng Town Health Center in Lanling County from January 2021 to January 2023 were selected as the study objects.All the children were divided into the control group(n=43)and the observation group(n=43)using the random number table method.The control group was treated with Oseltamivir Phosphate Granules,while the observation group was treated with Qingkailing Granules combined with Oseltamivir Phosphate Granules.The clinical efficacy,symptom improvement time,inflammatory indicators,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(95.35%)was higher than that in the control group(79.07%),and the difference was statistically significant(P<0.05).The improvement time of fever,cough,and nasal obstruction in the observation group was([1.15±0.14],[1.93±0.28],and[1.84±0.77]days),which was shorter than that in the control group([2.26±0.17],[2.21±0.42],and[3.49±1.05]days),and the difference was statistically significant(P<0.05).The level of C-reactive protein in the observation group was(9.87±2.13)mg/L,and the level of interferon-γwas(1.38±0.23)μg/L,which were lower than([12.98±2.24]g/L and[1.91±0.32]μg/L)in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group(6.98%)was lower than that in the control group(23.26%),and the difference was statistically significant(P<0.05).Conclusion The treatment of children with influenza with Qingkailing Granules combined with Oseltamivir Phosphate Granules can effectively alleviate symptoms,reduce inflammation indicators,and reduce the incidence of adverse reactions.