太子参配方颗粒+盐酸羟甲唑啉喷雾剂治疗儿童鼻窦炎的临床效果

Clinical Effect of Pseudostellaria Formula Granules+Hydroxymetazoline Hydrochloride Spray in the Treatment of Children's Sinusitis

目的探讨与分析太子参配方颗粒+盐酸羟甲唑啉喷雾剂治疗儿童鼻窦炎的临床效果。方法选取2022年9月—2023年6月在毕节市中医医院接受治疗的80例鼻窦炎患儿作为研究对象,根据1:1随机信封抽签法将80例患儿分为太子参组与对照组,各40例。两组患儿均接受鼻内镜手术治疗,对照组给予盐酸羟甲唑啉喷雾剂治疗,太子参组在对照组治疗的基础上给予太子参配方颗粒,均治疗观察4周,判定两组患儿的治疗效果。结果治疗4周后太子参组的总有效率高于对照组,差异有统计学意义(P<0.05)。治疗4周后太子参组与对照组的疼痛视觉模拟法(visual analog scale,VAS)量表评分都明显低于治疗前,且太子参组治疗4周后的疼痛VAS量表评分也低于对照组,差异有统计学意义(P<0.05)。治疗4周后太子参组与对照组的血清白细胞介素-2(interleukin-2,IL-2)、白细胞介素-6(interleukin-2,IL-6)含量明显均低于治疗前,且太子参组治疗4周后的IL-2、IL-6含量也明显低于对照组,差异有统计学意义(P<0.05)。太子参组治疗4周期间的鼻出血、鼻腔干燥、睡眠障碍、头晕等不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论太子参配方颗粒+盐酸羟甲唑啉喷雾剂治疗儿童鼻窦炎能缓解临床症状,提高患儿的总体治疗效果,能抑制IL-2、IL-6的表达,能降低不良反应发生率。

Objective To explore and analysis the clinical effects of Radix Pseudostellariae Formula Granules+Hydroxymetazoline Hydrochloride Spray in the treatment of children's Sinusitis.Methods A total of 80 cases of children with Sinusitis who were treated in n Bijie Traditional Chinese Medicine Hospital from September 2022 to June 2023 were selected as the study subjects.Accorded to the principle of 1:1 random envelope drawing,80 children were divided into the Pseudostellaria group of 40 cases and the control group of 40 cases.Both groups of children were received endoscopic surgery.The control group were treated with hydroxymethylazoline hydrochloride spray,and the Pseudostellaria group were treated with Pseudostellaria formula granules on the basis of the control group.Both groups were observed for 4 weeks,and were to determine the treatment eff ects of the two groups of children.Results After 4 weeks of treatment,the total eff ective rates of the Pseudostellaria group were 97.50%,while the control group were 85.00%.The Pseudostellaria group were signifi cantly higher than the control group(P<0.05).After 4 weeks of treatment,the pain VAS scores of the Pseudostellaria group and the control group were significantly lower than before treatment(P<0.05),and the pain VAS scores of the Pseudostellaria group after 4 weeks of treatment were also lower than the control group(P<0.05).After 4 weeks of treatment,the serum Interleukin 2 and Interleukin 6 levels in the Pseudostellaria group and the control group were signifi cantly lower than those before treatment(P<0.05),and the serum Interleukin 2 and Interleukin 6 levels in the Pseudostellaria group after 4 weeks of treatment were also signifi cantly lower than those in the control group(P<0.05).The incidence of adverse reactions such as epistaxis,nasal dryness,Sleep disorder and dizziness during the 4-week treatment period in the Pseudostellaria group were 5.00%,while that in the control group were 22.50%.The incidence of adverse reactions in the Pseudostellaria group were signifi cantly lower than that in the control group(P<0.05).Conclusion Pseudostellaria formula granule+hydroxymethylazoline hydrochloride spray can alleviate clinical symptoms,improve the overall therapeutic eff ect of children with Sinusitis,inhibit the expression of serum Interleukin 2 and Interleukin 6,and reduce the incidence of adverse reactions.