中国北方35~75岁社区居民颅内未破裂动脉瘤患病情况的调查研究

Investigation on the Prevalence of Unruptured Intracranial Aneurysms in Community Residents Aged 35-75 in Northern China

目的调查中国北方35~75岁社区居民颅内未破裂动脉瘤(UIA)的患病情况。方法2021年4月—2022年4月,在承德市鹰手营子矿区,根据2020年第七次全国人口普查结果中年龄和性别构成比确定各年龄段招募人数,其中35~44岁167名、45~54岁220名、55~64岁142名、65~75岁91名。以招募公告的形式招募志愿者,各年龄段招满即止。采用航天中心医院自制问卷面对面调查志愿者的临床资料;测量志愿者身高、体质量,并计算BMI;采用颅脑MRA 3D-TOF检查判断志愿者是否罹患UIA、UIA类型及动脉瘤位置、直径、形态。结果本研究共调查620名志愿者,其中罹患UIA 37名,UIA患病率为6.0%〔95%CI(4.1%~7.8%)〕。不同性别志愿者UIA患病率比较,差异无统计学意义(P>0.05)。在所有志愿者及男性、女性志愿者中,随着年龄增长UIA患病率不存在升高趋势(P>0.05)。UIA类型:1名(2.7%)为多发动脉瘤(2个动脉瘤),36名(97.3%)为单发动脉瘤,共38个动脉瘤。动脉瘤主要位于颈内动脉(占86.8%),动脉瘤直径多为3~<5 mm(占71.1%),动脉瘤主要形态为囊性(占97.4%)。结论中国北方35~75岁社区居民UIA患病率为6.0%,多为单发动脉瘤,动脉瘤主要位于颈内动脉、直径多为3~<5 mm、主要形态为囊性。

Objective To investigate the prevalence of unruptured intracranial aneurysms(UIA)in community residents aged 35-75 in northern China.Methods From April 2021 to April 2022,in Yingshouyingzi mining area of Chengde City,the number of recruits of all ages was determined according to the age and gender composition ratio in the seventh national census results in 2020,including 167 people aged 35-44,220 people aged 45-54,142 people aged 55-64,and 91 people aged 65-75.Volunteers were recruited in the form of recruitment announcements,and the recruitment of all ages was completed.The clinical data of volunteers was investigated face-to-face by self-made questionnaire in Aerospace Center Hospital.The height and weight of volunteers were measured,and BMI was calculated.Brain MRA 3D-TOF examination was used to determine whether the volunteers had UIA,the type of UIA,the location,diameter and morphology of aneurysms.Results A total of 620 volunteers were investigated in this study,of which 37 suffered from UIA,and the prevalence of UIA was 6.0%[95%CI(4.1%-7.8%)].There was no significant difference in the prevalence of UIA among volunteers with different gender(P>0.05).Among all volunteers,male volunteers and female volunteers,the prevalence of UIA did not increase with age(P>0.05).UIA type:1 case(2.7%)was multiple aneurysms(2 aneurysms),36 cases(97.3%)were single aneurysms,and there were a total of 38 aneurysms.Aneurysms were mainly located in the internal carotid artery(86.8%).The diameter of aneurysms was mostly greater than or equal to 3 mm and less than 5 mm(71.1%).The main morphology of aneurysms was cystic(97.4%).Conclusion The prevalence of UIA in community residents aged 35-75 in northern China is 6.0%.Most of them are single aneurysms.The aneurysms are mainly located in the internal carotid artery,with a diameter greater than or equal to 3 and less than 5,and the main form is cystic.