三阴性乳腺癌患者血清组织多肽抗原和糖类抗原的表达及其对复发的预测价值

Correlation of serum tissue polypeptide antigen and carbohydrate antigen expression in triple-negative breast cancer and their predictive value for postoperative recurrence events

目的探讨三阴性乳腺癌(triple-negative breast cancer,TNBC)患者血清组织多肽抗原(tissue polypeptide antigen,TPA)与糖类抗原(carbohydrate antigen)CA15-3表达的相关性及其对术后复发事件的预测价值。方法对组织多肽抗原TPA和糖类抗原CA15-3在三阴性乳腺癌和非三阴乳腺癌患者血清中的表达水平进行组间比较。三阴性乳腺癌患者血清TPA、CA15-3表达的相关性及临床意义进行分析。依据TNBC患者稳定期与术后复发患者检测结果,分析TPA、CA15-3表达对短期复发事件的影响及术后短期复发事件的预测效能。结果三阴性乳腺癌与非三阴乳腺癌患者血清TPA、CA15-3表达水平及TNBC早期、中期患者组间比较,差异有统计学意义(P<0.05)。经Pearson相关性分析,三阴性乳腺癌患者血清TPA、CA15-3表达相关系数在0.01的水平上呈显著正相关。TNBC患者术后复发事件与稳定期组患者血清TPA、CA15-3表达水平比较,差异有统计学意义(P<0.01)。三阴性乳腺癌患者血清TPA、CA15-3表达水平的ROC曲线分析结果显示,预测效能敏感度、特异度有统计学意义。结论组织多肽抗原TPA与糖类抗原CA15-3可能是三阴性乳腺癌患者预后的预测靶基因,作为复发事件的生物学观察指标,具有重要的临床意义。

Objective To investigate the correlation between serum tissue polypeptide antigen(TPA)and carbohydrate antigen CA15-3 expression in triple-negative breast cancer(TNBC)patients and their predictive value for postoperative recurrence events.Methods The expression levels of TPA and carbohydrate antigen CA15-3 in the serum of TNBC and non-TNBC patients were compared.The correlation and clinical significance of serum TPA and CA15-3 expression in TNBC patients were analyzed.Based on the results of stable and postoperative recurrence patients in TNBC,the impact of TPA and CA15-3 expression on short-term recurrence events and the predictive efficacy for short-term postoperative recurrence events were analyzed.Results The expression levels of serum TPA and CA15-3 in TNBC and non-TNBC patients,as well as among the early and middle TNBC patients,were statistically significant(P<0.05).Pearson correlation analysis showed a significant positive correlation between serum TPA and CA15-3 expression in TNBC patients at the 0.01 level.The comparison of serum TPA and CA15-3 expression levels between postoperative recurrence and stable period groups in TNBC patients was statistically significant(P<0.01).ROC curve analysis of serum TPA and CA15-3 expression levels in TNBC patients showed statistically significant sensitivity and specificity in predicting efficacy.Conclusion TPA and carbohydrate antigen CA15-3 may serve as predictive target genes for the prognosis of TNBC patients and have important clinical significance as biological indicators for recurrence events.These findings highlight the potential role of TPA and CA15-3 as valuable markers for short-term recurrence risk assessment in TNBC patients.