阿托西班联合地塞米松对胎膜早破孕妇的治疗效果及对8-iso-PG、Cor、NE水平的影响

The therapeutic effect of atosiban combined with dexamethasone on pregnant women with premature rupture of membranes and its influence on 8-iso-PG,Cor and NE levels

目的探讨阿托西班联合地塞米松对胎膜早破孕妇的治疗效果及对氧化应激反应指标[8-异前列腺素(8-iso-PG)、皮质醇(Cor)、去甲肾上腺素(NE)]水平的影响。方法选取2019年10月至2021年10月河北省保定市第二医院收治的110例胎膜早破患者作为研究对象。按照随机数字表法分为观察组与对照组,每组55例。两组均给予胎膜早破的常规治疗,对照组在常规治疗基础上增加地塞米松治疗,观察组在对照组基础上联合阿托西班治疗。比较两组治疗后临床疗效、症状改善指标、不良母婴结局、氧化应激指标、治疗安全性。结果治疗后观察组治疗总有效率为92.73%(51/55),高于对照组的76.36%(42/55),差异有统计学意义(P<0.05)。治疗后观察组药物显效时间、宫缩抑制时间均短于对照组(P<0.05),孕期延长时间长于对照组(P<0.05)。治疗后观察组剖宫产、产后出血、羊膜腔感染、胎儿窘迫、新生儿窒息等发生率均低于对照组(P<0.05)。两组治疗后8-iso-PG、Cor、NE水平均低于同组治疗前(P<0.05),且观察组治疗后8-iso-PG、Cor、NE水平均低于对照组(P<0.05)。治疗期间观察组、对照组不良反应发生率分别为14.55%(8/55)、9.09%(5/55),两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿托西班联合地塞米松对胎膜早破患者的治疗效果良好,可抑制患者的宫缩,延长孕期时间,改善孕产妇的母婴结局,抑制8-iso-PG、Cor、NE水平,且治疗安全性较好。

Objective To investigate the therapeutic effect of atosiban combined with dexamethasone on pregnant women with premature rupture of membranes and its influence on oxidative stress response indicators[8-iso-prostaglandin(8-iso-PG),cortisol(Cor),norepinephrine(NE)]levels.Methods A total of 110 patients with premature rupture of membranes admitted to the Second Hospital of Baoding in Hebei Province from October 2019 to October 2021 were selected as the research objects.According to the random number table method,they were divided into observation group and control group,with 55 cases in each group.Both groups were given conventional treatment of premature rupture of membranes,the control group was treated with dexamethasone on the basis of conventional treatment,and the observation group was treated with atosiban on the basis of the control group.The clinical efficacy,symptom improvement indicators,adverse maternal and infant outcomes,oxidative stress indicators and treatment safety were compared between the two groups after treatment.Results After treatment,the total effective rate of the observation group was 92.73%(51/55),which was higher than 76.36%(42/55)of the control group,and the difference was statistically significant(P<0.05).After treatment,the drug effective time and uterine contraction inhibition time of the observation group were lower than those of the control group(P<0.05),and the prolonged duration of pregnancy pomfret control group(P<0.05).After treatment,the incidence of cesarean section,postpartum hemorrhage,amniotic cavity infection,fetal distress and neonatal asphyxia in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of 8-iso-PG,Cor and NE in the two groups were lower than those before treatment(P<0.05),and the levels of 8-iso-PG,Cor and NE in the observation group were lower than those in the control group(P<0.05).During the treatment,the incidence of adverse reactions in the observation group and the control group was 14.55%(8/55)and 9.09%(5/55)respectively,and there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Atosiban combined with dexamethasone has a good therapeutic effect on patients with premature rupture of membranes,which can inhibit the uterine contraction of patients,prolong the pregnancy time,improve the maternal and infant outcomes of pregnant women,and inhibit the levels of 8-iso-PG,Cor and NE,and the treatment safety is good.