富血小板血浆技术联合伤口治疗师主导的综合管理在骨科住院老年患者压力性损伤中的应用

Application of platelet-rich plasma technology combined with wound therapists-led comprehensive management in pressure ulcers in elderly orthopedic inpatients

目的探讨富血小板血浆(PRP)技术联合伤口治疗师主导的综合管理在骨科住院的老年患者压力性损伤中的治疗效果。方法选取2022年1月—2024年1月于西安医学院第二附属医院骨科收治的压力性损伤老年患者60例,采用数字表法随机分为对照组和观察组2组,每组30例。对照组采用湿性愈合敷料对伤口进行常规治疗,观察组在对照组治疗的基础上加用PRP技术和伤口治疗师实施综合管理。比较2组创面愈合时间、愈合率及疼痛情况(采用VAS评估);比较2组治疗前后炎性因子(CRP、IL-6及TNF-α)水平及并发症发生率。结果治疗后,观察组患者创面愈合时间明显短于对照组[(16.28±2.81)d vs(22.91±5.04)d],愈合率显著高于对照组(86.7%vs 56.7%),VAS评分低于对照组[(1.45±0.38)vs(3.68±0.41)],治疗总有效率明显高于对照组(93.3%vs 66.7%),差异均有统计学意义(P<0.05);2组患者CRP、IL-6及TNF-α水平低于同组治疗前,观察组血清CRP、IL-6及TNF-α水平均低于对照组,差异均有统计学意义(P<0.05)。2组患者并发症发生率差异无统计学意义(P>0.05)。结论PRP技术联合伤口治疗师主导的综合管理在骨科住院老年患者压力性损伤中的治疗效果显著,具有一定临床应用价值。

Objective To investigate the effects of platelet-rich plasma(PRP)technology combined with wound therapist-led comprehensive management in the treatment of pressure ulcers in elderly orthopedic inpatients.Methods Sixty elderly patients with pressure ulcers admitted to Department of Orthopedics,Second Affiliated Hospital of Xi'an Medical College from January 2022 to January 2024 were selected and randomly divided into control group and observation group by digital table method,with 30 cases in each group.The control group was treated with wet healing dressing.On the basis of the treatment of the control group,the observation group was treated with PRP technology and wound therapist-led comprehensive management.The wound healing time,healing rate and pain degree(VAS score)of the two groups were compared.The levels of inflammatory factors(serum CRP,IL-6 and TNF-α)and the incidence of complications were compared between the two groups before and after treatment.Results After treatment,the wound healing time of the observation group was significantly shorter than that of the control group[(16.28±2.81)d vs(22.91±5.04)d],the healing rate was significantly higher than that of the control group(86.7%vs 56.7%),the VAS score was lower than that of the control group[(1.45±0.38)vs(3.68±0.41)],and the total effective rate of treatment was significantly higher than that of the control group(93.3%vs 66.7%),and the differences were statistically significant(P<0.05).The levels of CRP,IL-6 and TNF-α in both groups after treatment were lower than those of the same group before treatment,and the levels of CRP,IL-6 and TNF-α in the observation group after treatment were lower than those in the control group,with statistical significance(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion The combination of PRP technology and wound therapist-led comprehensive management has significant therapeutic effects on pressure ulcers in elderly orthopedic inpatients,and has certain clinical application value.