运动疗法对脑出血神经保护作用机制的研究进展

Research progress on the neuroprotective mechanism of exercise therapy on cerebral hemorrhage

脑出血(ICH)是一种严重危害人类健康的疾病,ICH后的功能障碍带来较高的致残率,已成为一个严重的公共卫生问题。因此,探索有效预防和治疗ICH的康复方法至关重要。运动疗法改善ICH后功能障碍的有效性显而易见,可促进血管生成、神经再生和突触可塑性,减轻ICH后的炎症反应、氧化应激和细胞凋亡发挥神经保护作用。然而,运动疗法在ICH中发挥神经保护作用的分子机制仍然未知。因此,该文通过回顾运动疗法防治ICH的临床和动物实验证据,以期揭示运动疗法潜在的神经保护机制,为运动疗法在ICH功能康复领域提供一定的理论依据。

Intracerebral hemorrhage(ICH) is a serious disease that endangers human health.Dysfunction after ICH brings a high disability rate and has become a serious public health problem.Therefore,it is very important to explore effective rehabilitation methods for the prevention and treatment of ICH.The effectiveness of exercise therapy in improving dysfunction after ICH is obvious.It can promote angiogenesis,nerve regeneration and synaptic plasticity,and reduce inflammatory response,oxidative stress and apoptosis after ICH to play a neuroprotective role.However,the molecular mechanism by which exercise therapy plays a neuroprotective role in ICH remains unknown.Therefore,this article reviewed the clinical and animal experimental evidence of exercise therapy in the prevention and treatment of ICH,in order to reveal the potential neuroprotective mechanism of exercise therapy,and provide a theoretical basis for exercise therapy in the field of ICH functional rehabilitation.