1例复杂性尿路感染合并继发性癫痫患者的药物治疗分析

Analysis of Drug Therapy in A Patient with Complicated Urinary Tract Infection with Secondary Epilepsy

目的:临床药师通过参与1例复杂性尿路感染患者的治疗过程,从初始抗感染治疗失败原因分析、协助调整治疗方案和抗菌药物不良反应识别等方面作为工作切入点,为临床抗感染治疗提供思路及参考依据。方法:临床药师在查阅指南和文献资料等循证证据基础上,结合临床疗效评估和诱发癫痫药物相关性辨识,协助医生调整抗感染治疗方案。结果:患者通过2次抗感染药物调整后治疗有效且癫痫未再发生。结论:对于复杂性尿路感染患者,应重视真菌性尿培养结果。对于老年糖尿病伴血清白蛋白降低患者,在使用厄他培南治疗时需警惕癫痫的发生。

Objective:Through clinical pharmacists'participating in the treatment of a patient with complicated urinary tract infection,to analyze the failure of initial anti-infective therapy,assist in adjusting the treatment regimen and identify the adverse reactions of antibiotics,so as to provide ideas and reference for clinical anti-infective therapy.Methods:Clinical pharmacists assisted physicians to adjust anti-infective treatment regimen based on evidences such as guidelines and literature,as well as clinical efficacy evaluation and identification of the association between the epilepsy and medicines.Results:The patient responded to the treatment and experienced no recurrence of epilepsy after two adjustments of anti-infective medications.Conclusion:Fungal urine culture results should be emphasized in patients with complicated urinary tract infection,and the occurrence of epilepsy should be paid attention to when ertapenem is used in the elderly patients with decreased serum albumin.