温热类中药在治疗原发性肝癌中的应用及机制

Application and Mechanism of Warm Traditional Chinese Medicine in the Treatment of Primary Liver Cancer

肝癌作为临床常见的难治性肿瘤,死亡率一直高居不下。传统医学在对于肝癌治疗方面有着独特的理论体系和方法。立足于经典,从《素问·阴阳应象大论》中挖掘“阳化气,阴成形”初步了解阴阳功能,以及《灵枢·百病始生》“积之始生,得寒乃生”的论述中得出肿瘤具备“阴”的属性;加上肝脏“体阴而用阳”的生理属性,认为温热类中药在原发性肝癌治疗中的应用值得关注。文章从温阳散寒的角度综述了温热类中药在治疗肝癌中的临床应用情况,并从不同温热类中药在肝癌的基础实验中寻找证据,得出在肝癌的治疗中不能只关注清热解毒的方法,也应该注意到温阳散寒的应用。为肝癌的临床治疗提供了不同的思路。

Liver cancer,as a common and difficult to treat tumor in clinical practice,has always had a high mortality rate.Traditional medicine has a unique theoretical system and methods for the treatment of liver cancer.Based on the classics,this study explores the function of Yin and Yang by exploring the concept of“Yang transforming Qi and Yin forming shape”,as well as the discussion in Ling Shu,which concludes that tumors possess the attribute of“Yin”;Combined with the physiological attribute of the liver s“body Yin and using Yang”,it is believed that the application of warm and hot traditional Chinese medicine in the treatment of primary liver cancer is worth paying attention to.The article reviews the clinical application of warm and hot traditional Chinese medicine in the treatment of liver cancer from the perspective of warming Yang and dispersing cold.Evidence is sought from basic experiments of different warm and hot traditional Chinese medicine in liver cancer,and it is concluded that in the treatment of liver cancer,attention should not only be paid to the methods of clearing heat and detoxifying,but also to the application of warming Yang and dispersing cold.Provided different approaches for the clinical treatment of liver cancer.