慢性胰腺炎抗炎和抗纤维化治疗的研究进展

Research progress on anti-inflammatory and anti-fibrotic therapy for chronic pancreatitis

慢性胰腺炎(CP)以胰腺慢性炎症及纤维化为特征,胰腺腺泡细胞损伤、星状细胞活化及炎症细胞浸润共同影响疾病进程。长期以来,CP治疗以控制症状和防治并发症为主,临床上暂无干预疾病发展的有效药物。因此,寻找可干预的分子靶点和药物是CP研究的重要方向。本文综述了CP的发病机制及抗炎抗纤维化治疗研究进展,以期为CP的治疗提供更多选择。

Chronic pancreatitis(CP)is characterized by chronic inflammation and fibrosis of the pancreas,with pancreatic acinar cell injury,stellate cell activation,and inflammatory cell infiltration collectively influencing the disease process.For a long time,the treatment of CP has focused on controlling symptoms and preventing complications,with no effective drugs available for intervening in the disease progression clinically.Therefore,the search for molecular targets and drugs that could be intervened is an important direction in CP research.This article reviews the pathogenesis of CP and the progress in anti-inflammatory and anti-fibrotic treatment research,aiming to provide more treatment options for CP.