空间微重力下细胞力学感知-传导的研究进展

Research Progress of Cellular Mechanoperception&Mechanotransmission under Space Microgravity

在重力场下,绝大多数细胞功能受到力学载荷的调控。空间微重力下细胞对力学载荷的响应能力在空间机体生理功能适应性变化中的作用不容忽视。细胞骨架被普遍认为是细胞感知重力变化及响应力学载荷的关键结构之一。本文总结了微重力下“细胞骨架-LINC复合物-核纤层”这一细胞力学感知-传导途径变化及作用机制的研究进展,并对未来的研究工作进行展望。

On the earth,the majority of cellular functions are regulated by mechanical loads.The effects of cell response to mechanical loads under microgravity on the adaptive changes of physiological functions in space cannot be ignored.The cytoskeleton is widely considered as one of the key structures through which cells sense gravity variation and respond to mechanical loads.In this review,the research progress on the changes and mechanisms of the‘cytoskeleton-LINC complex-nuclear lamina’pathway in cellular mechanoperception and mechanotransmission under microgravity is summarized,and the future research is prospected.