基于仿生物理模型的半规管壶腹嵴顶变形

Deformation of the Cupula of a Semicircular Canal Based on a Biomimetic Physical Model

目的 探讨人类半规管在3种基本旋转感知过程中的生物力学响应。方法 采用3D打印技术及水凝胶物理交联技术成功制备了与人体等比例的一维可视化半规管物理模型,并通过施加恒定角速度刺激、恒定角加速度刺激以及正弦摆动刺激来探究嵴顶的响应变形情况。结果 仿生半规管模型的时间常数基本稳定在3 s左右,且与人体时间常数数值接近,壶腹嵴顶运动的位移变形与施加的角加速度成正比;在0.07~5.00 Hz正弦摆动刺激下,半规管的增益从1.54μm/°上升到42.34μm/°,但相位差从109.72°下降到11.27°。结论 制备的仿生半规管模型能够准确模拟人体半规管的工作机制,有望在人体前庭半规管的机理研究和疾病诊断中发挥一定作用。

Objective To explore the biomechanical responses of the cupula of the human semicircular canal to three basic rotational perception processes.Methods A one-dimensional visual semicircular canal model was successfully fabricated using three-dimensional printing and hydrogel physical cross-linking technologies,and the response deformation of the cupula was explored by applying constant angular velocity,constant angular acceleration,and sinusoidal oscillation stimulations.Results The time constant of the biomimetic semicircular canal model was stable at approximately 3 s and close to the human time constant.The displacement deformation of the ampullary cupula was proportional to the angular acceleration applied.Under sinusoidal oscillation stimulation of 0.07-5.00 Hz,the gain of the semicircular canal increased from 1.54μm/°rises to 42.34μm/°,but the phase difference decreased from 109.72°to 11.27°.Conclusions The biomimetic semicircular canal model prepared in this study can accurately simulate the working mechanism of the human semicircular canal and is expected to play a role in mechanism research and disease diagnosis of the human vestibular semicircular canal.