重组贻贝粘蛋白在点阵CO_(2)激光治疗面部痤疮萎缩性瘢痕术后创面修复中的应用研究

Application of Rmaphd in Wound Repair after Fractional CO_(2) Laser Treatment of Atrophic Scar of Facial Acne

目的:探究重组贻贝粘蛋白水凝胶敷料(Recombined mussel adhesive protein hydrogel dressing,Rmaphd)在点阵CO_(2)激光治疗面部痤疮萎缩性瘢痕术后创面修复中的应用效果。方法:选择2022年6月-2023年2月面部痤疮萎缩性瘢痕患者117例,分为Rmaphd组、重组人表皮生长因子(Recombinant human epidermal growth factor,rhEGF)组和对照组,每组39例,三组均给予点阵CO_(2)激光术治疗,术后分别给予Rmaphd、rhEGF及生理盐水处理,比较三组疗效、ECCA评分、症状持续时间以及生活质量评分。结果:Rmaphd组和rhEGF组总有效率分别为92.31%和94.87%,均高于对照组76.92%(P<0.05),术后ECCA评分低于对照组(P<0.05),术后疼痛、红斑、痂皮持续时间短于对照组(P<0.05),Acne-QoL各指标得分优于对照组(P<0.05);上述各临床Rmaphd组与rhEGF组差异无统计学意义(P>0.05)。结论:Rmaphd用于点阵CO_(2)激光治疗面部痤疮萎缩性瘢痕术后创面修复疗效显著,具备在临床上辅助激光治疗术后修复的应用潜力。

Objective To investigate the effect of recombinant mussel mucin hydrogel dressing(Rmaphd)in wound repair after fractional CO_(2) laser surgery.Methods 117 patients with atrophic scars of facial acne treated between June 2022 to February 2023 were divided into the Rmaphd group,the recombinant human epidermal growth factor(rhEGF)group and the control group and 39 patients in each group.All patients were treated with fractional CO_(2) laser.After the operation,Rmaphd,rhEGF and normal saline were applied separately.The efficacy,ECCA score,duration of symptoms and quality of life scores were compared among groups.Results The total effective rate of Rmaphd group and rhEGF group were 92.31%and 94.87%,respectively,which were higher than that of control group(76.92%)(P<0.05).The postoperative ECCA score was lower than that of control group(P<0.05).The duration of postoperative pain,erythema and crust was shorter than that of control group(P<0.05).The Acne-QoL scores were better than those of the control group(P<0.05).There was no statistical difference between Rmaphd group and rhEGF group(P>0.05).Conclusion Rmaphd combined with fractional CO_(2) laser can effectively eliminate atrophic scar of facial acne,demonstrating potential as an adjunctive treatment in clinical practice.